Evidence map›Paper›PMID 33256599›Full record

ArticleBMC genomics2020

A general index for linear and nonlinear correlations for high dimensional genomic data.

Zhihao Yao, Jing Zhang, Xiufen Zou

Open access · goldAbstract read
In one paragraph

Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhihao YaoSchool of Mathematics and Statistics, Wuhan University, Wuhan, 430072, China.
Jing ZhangSchool of Mathematics and Statistics, Wuhan University, Wuhan, 430072, China.
Xiufen ZouSchool of Mathematics and Statistics, Wuhan University, Wuhan, 430072, China. xfzou@whu.edu.cn.
Wuhan University · CN

Funding

National Key Research and Development Program of China 2018YFC1314600National Natural Science Foundation of China 11801207National Natural Science Foundation of China 11831015Natural Science Foundation of Hubei Province 2019CFA007
6 · The paper itself

Abstract

backgroundWith the advance of high throughput sequencing, high-dimensional data are generated. Detecting dependence/correlation between these datasets is becoming one of most important issues in multi-dimensional data integration and co-expression network construction. RNA-sequencing data is widely used to construct gene regulatory networks. Such networks could be more accurate when methylation data, copy number aberration data and other types of data are introduced. Consequently, a general index for detecting relationships between high-dimensional data is indispensable.

resultsWe proposed a Kernel-Based RV-coefficient, named KBRV, for testing both linear and nonlinear correlation between two matrices by introducing kernel functions into RV

conclusionsWe concluded that KBRV is an efficient index for detecting both linear and nonlinear relationships in high dimensional data. The correlation method for high dimensional data has possible applications in the construction of gene regulatory network.

Indexed as

Gene Regulatory NetworksOvarian NeoplasmsFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansSequence Analysis, RNAHigh-dimensional dataNonlinear correlationRV-coefficient

Identifiers

PMID33256599
PMCPMC7706065
OpenAlexW3110466475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.