Evidence map›Paper›PMID 33256492›Full record

ReviewExpert opinion on drug metabolism & toxicology2021

Potential implications of DMET ontogeny on the disposition of commonly prescribed drugs in neonatal and pediatric intensive care units.

Siavosh Naji-Talakar, Sheena Sharma, Leslie A Martin, Derek Barnhart, Bhagwat Prasad

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug metabolism & toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05365451 (Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05365451 early_phase1completednot on this mapstarted 2022, after this paper: background citation

Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters

TypeinterventionalSponsorWashington State UniversityRan2022 to 2023Enrolled16ConditionsInteraction, Endogenous BiomarkersArmsMetFORMIN Oral Solution, Cimetidine 400 MG, Furosemide Oral Liquid Product, Probenecid 500 MG
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Siavosh Naji-TalakarDepartment of Pharmaceutical Sciences, Washington State University, Spokane, USA.
Sheena SharmaDepartment of Pharmaceutical Sciences, Washington State University, Spokane, USA.
Leslie A MartinPediatrics and Neonatology, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, USA.
Derek BarnhartPediatrics and Neonatology, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, USA.
Bhagwat PrasadDepartment of Pharmaceutical Sciences, Washington State University, Spokane, USA.
Washington State University Spokane · USProvidence Sacred Heart Medical Center · US

Funding

PBPK prediction of ontogeny mediated alteration in hepatic drug eliminationR01HD081299 · NICHD · WASHINGTON STATE UNIVERSITY · PI PRASAD, BHAGWAT · 2015 to 2025
$4.6M
NICHD NIH HHS R01 HD081299
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Age FactorsAnimalsChildDrug-Related Side Effects and Adverse ReactionsHumansInactivation, MetabolicInfantInfant, NewbornIntensive Care Units, NeonatalIntensive Care Units, PediatricMembrane Transport ProteinsModels, BiologicalPharmaceutical PreparationsMembrane Transport ProteinsPharmaceutical Preparationsdevelopmental toxicitydrug metabolismdrug transportontogenypediatric pharmacologyPediatric precision medicine

Identifiers

PMID33256492
PMCPMC8346204
OpenAlexW3107953662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.