Evidence map›Paper›PMID 33256233›Full record

ArticleMetabolites2020

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data.

Tariq Faquih, Maarten van Smeden, Jiao Luo, Saskia le Cessie, Gabi Kastenmüller, Jan Krumsiek, Raymond Noordam, Diana van Heemst, Frits R Rosendaal, Astrid van Hylckama Vlieg and 2 more

Abstract read
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Alterations of Plasma Metabolites Associated with Sickle Cell Trait.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  8. Article
  9. The Metabolomic Signature of Stressful Life Events.medRxiv : the preprint server for health sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tariq FaquihDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-8026-2251
Maarten van SmedenJulius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, 8, 3584 Utrecht, The Netherlands.
Jiao LuoDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.
Saskia le CessieDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.
Gabi KastenmüllerInstitute of Bioinformatics and Systems Biology, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.
Jan KrumsiekDepartment of Physiology, Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333ZA Leiden, The Netherlands.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333ZA Leiden, The Netherlands.ORCID 0000-0001-8526-7748
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.
Astrid van Hylckama VliegDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.
Ko Willems van DijkEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2, 2333 Leiden, The Netherlands.ORCID 0000-0002-2172-7394
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Postal Zone C7-P, PO Box 9600, 2300 RC Leiden, The Netherlands.

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
China Scholarship Counsel 201808500155NHLBI NIH HHS R01 HL105756VELUX Stiftung 1156ZonMW-VENI Grant 916.14.023
6 · The paper itself

Abstract

Metabolomics studies have seen a steady growth due to the development and implementation of affordable and high-quality metabolomics platforms. In large metabolite panels, measurement values are frequently missing and, if neglected or sub-optimally imputed, can cause biased study results. We provided a publicly available, user-friendly

Indexed as

imputationk-nearest neighborsmetabolonmultiple imputation using chained equationssimulationuntargeted metabolomicsworkflow

Identifiers

PMID33256233
PMCPMC7761057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.