Evidence map›Paper›PMID 33256207›Full record

ReviewMolecules (Basel, Switzerland)2020

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches.

Roxana Ghiulai, Oana Janina Roşca, Diana Simona Antal, Marius Mioc, Alexandra Mioc, Roxana Racoviceanu, Ioana Macaşoi, Tudor Olariu, Cristina Dehelean, Octavian Marius Creţu and 2 more

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Therapeutic potential ofPharmaceutical biology · 2026
    Review
  2. Review
  3. Article
  4. Molecules (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roxana GhiulaiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Oana Janina RoşcaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Diana Simona AntalDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.ORCID 0000-0001-8107-8595
Marius MiocDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Alexandra MiocDepartment of Anatomy, Physiology, Pathophysiology, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Roxana RacoviceanuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.ORCID 0000-0002-3378-0774
Ioana MacaşoiDepartment of Toxicology, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania.
Tudor OlariuDepartment of Organic Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania.
Cristina DeheleanDepartment of Toxicology, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania.
Octavian Marius CreţuDepartment of Surgery, Faculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania.
Mirela VoicuDepartment of Pharmacology, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd EftimieMurgu Sq., 300041 Timişoara, Romania.
Codruţa ŞoicaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.

Funding

"Victor Babes" University of Medicine and Pharmacy, Timisoara 1EXP/1233/30.01.2020 LUPSKINPATH
6 · The paper itself

Abstract

Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.

Indexed as

AnimalsClinical Trials as TopicDrug Evaluation, PreclinicalHumansMolecular ConformationMolecular StructurePentacyclic TriterpenesPlant ExtractsSkinSkin DiseasesSkin Physiological PhenomenaStructure-Activity RelationshipTreatment OutcomeWound HealingPentacyclic TriterpenesPlant Extractspentacyclic triterpenestetracyclic triterpeneswound healing

Identifiers

PMID33256207
PMCPMC7730621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.