ReviewAntioxidants (Basel, Switzerland)2020
Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies.
Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.Asia Pacific journal of clinical nutrition · 2025Pooled it
- The janus-faced extracellular matrix remodeling in acute lung injury: a gatekeeper of macrophage localization and phenotype.Science China. Life sciences · 2026Article
- Redox-Dependent Modulation of Cardiac Mitochondrial FBiology · 2026Article
- Integrative multidisciplinary oncological approach in cancer patients receiving oncological treatments: a case series.Frontiers in pharmacology · 2026Article
- L-ascorbate prevents non-alcoholic steatohepatitis-based hepatocarcinogenesis in Sod1/Prdx4 double-knockout mice.Scientific reports · 2025Article
- Pathophysiological Role and Therapeutic Potential of Vitamin C in Metabolic Syndrome and Type 2 Diabetes Mellitus.Metabolites · 2025Review
- Development of a multi-source blue light irradiation platform for photometric quantification of ascorbic acidRSC advances · 2025Article
- Nitrogen Doped Carbon Quantum Dots as Fluorescence "Turn-Off-On" Sensor for Detection of FeJournal of fluorescence · 2025Article
- Multidisciplinary Integrative Medicine Approach for Cancer Patients: A Multicenter Retrospective Study.Nutrients · 2025Observational
- Oxidative Stress by HAntioxidants (Basel, Switzerland) · 2025Article
- Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential.Molecules (Basel, Switzerland) · 2025Review
- Oxidized HDL as a Novel Predictive Biomarker in Conjunction with Selected Inflammatory Variables in Severe Dengue Fever Patients from Lahore, Pakistan.Current molecular medicine · 2025Article
- Review
- Effect of Ascorbic Acid on Oxidative Stress Parameters of Fruit Fly in the Presence of Fe (II).Biological trace element research · 2024Article
- Arazá:Foods (Basel, Switzerland) · 2024Review
- Blood Vitamin C Levels of Patients Receiving Immunotherapy and Relationship to Monocyte Subtype and Epigenetic Modification.Epigenomes · 2024Article
- Vitamin C as Scavenger of Reactive Oxygen Species during Healing after Myocardial Infarction.International journal of molecular sciences · 2024Review
- Arthritis alleviation: unveiling the potential inFuture science OA · 2024Article
- Metabolic Profiling of Rat Kidney Tissue Following Administration of D-Allulose.Journal of applied glycoscience · 2024Article
- Therapeutic potential role of vitamin C in prevention and control of heart transplant rejection and cardiac allograft vasculopathy. A need for consideration.Health science reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe disease commonly manifests as a systemic inflammatory process. Inflammation is associated withthe enhanced production of reactive oxygen and nitrogen species and with a marked reduction in the plasma concentrations of protective antioxidant molecules. This imbalance gives rise to oxidative stress, which is greater in patients with more severe conditions such as sepsis, cancer, cardiovascular disease, acute respiratory distress syndrome, and burns. In these patients, oxidative stress can trigger cell, tissue, and organ damage, thus increasing morbidity and mortality. Ascorbic acid (ASC) is a key nutrient thatserves as an antioxidant and a cofactor for numerous enzymatic reactions. However, humans, unlike most mammals, are unable to synthesize it. Consequently, ASC must be obtained through dietary sources, especially fresh fruit and vegetables. The value of administering exogenous micronutrients, to reestablish antioxidant concentrations in patients with severe disease, has been recognized for decades. Despite the suggestion that ASC supplementation may reduce oxidative stress and prevent several chronic conditions, few large, randomized clinical trials have tested it in patients with severe illness. This article reviews the recent literature on the pharmacological profile of ASC and the role of its supplementation in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.