Evidence map›Paper›PMID 33255984›Full record

ArticleJournal of personalized medicine2020

Helpful Criteria When Implementing NGS Panels in Childhood Lymphoblastic Leukemia.

Nerea Vega-Garcia, Rocío Benito, Elena Esperanza-Cebollada, Marta Llop, Cristina Robledo, Clara Vicente-Garcés, Javier Alonso, Eva Barragán, Guerau Fernández, Jesús M Hernández-Sánchez and 18 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 1 country.

Nerea Vega-GarciaHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.
Rocío BenitoIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, 37008 Salamanca, Spain.ORCID 0000-0001-9781-4198
Elena Esperanza-CebolladaHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0001-5451-0370
Marta LlopMolecular Biology Unit, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
Cristina RobledoUnidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, 28222 Madrid, Spain.
Clara Vicente-GarcésHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.ORCID 0000-0002-2556-043X
Javier AlonsoUnidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, Majadahonda, 28222 Madrid, Spain.ORCID 0000-0002-6287-8391
Eva BarragánMolecular Biology Unit, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
Guerau FernándezMolecular and Genetics Medicine Section, Hospital Sant Joan de Déu, Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.
Jesús M Hernández-SánchezIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, 37008 Salamanca, Spain.
Marta Martín-IzquierdoIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, 37008 Salamanca, Spain.
Joan MaynouMolecular and Genetics Medicine Section, Hospital Sant Joan de Déu, Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.
Alfredo MinguelaImmunology Service, Virgen de la Arrixaca Clinic University Hospital, Biomedical Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain.ORCID 0000-0003-2472-5893
Adrián MontañoIBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, 37008 Salamanca, Spain.ORCID 0000-0002-3178-6726
Margarita OrtegaDepartment of Hematology, University Hospital Vall d'Hebron, University Autònoma of Barcelona (UAB), 08035 Barcelona, Spain.
Montserrat TorrebadellHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.
José CerveraHematology Service and Genetics Unit, Hospital de La Fe, 46026 Valencia, Spain.
Joaquín SánchezHematology Department, Hospital Reina Sofía, IMIBIC, University of Córdoba, 14004 Córdoba, Spain.
Antonio Jiménez-VelascoHematology and Hemotherapy Laboratory, Hospital Carlos Haya, 29010 Málaga, Spain.
Susana RiescoPediatric Service, Hospital Universitario de Salamanca-IBSAL, 37007 Salamanca, Spain.
Jesús M Hernández-RivasHematology Service, Hospital Universitario de Salamanca-IBSAL-USAL, 37007 Salamanca, Spain.
Álvaro LassalettaDepartment of Pediatric Hematology & Oncology, Hospital Universitario Niño Jesús, 28009 Madrid, Spain.ORCID 0000-0003-2881-1473
José María FernándezPediatric Oncohematology Unit, Hospital de La Fe, 46026 Valencia, Spain.
Susana RivesLeukemia and other Pediatric Hemopathies, Developmental Tumors Biology Group, Institut de Recerca Hospital Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain.
José Luis DapenaLeukemia and other Pediatric Hemopathies, Developmental Tumors Biology Group, Institut de Recerca Hospital Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain.
Manuel RamírezHematology Laboratory, Hospital Niño Jesús, 28009 Madrid, Spain.ORCID 0000-0003-0332-6973
Mireia CamósHematology Laboratory, Hospital Sant Joan de Déu Barcelona, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain.
On Behalf Of The Group Of Leukemia Of The Spanish Society Of Pediatric Hematology And Oncology Sehop
Hospital Sant Joan de Déu Barcelona · ESUniversidad de Salamanca · ESHospital Infantil Universitario Niño Jesús · ESHospital Universitari i Politècnic La Fe · ESInstituto de Investigación Biomédica de Salamanca · ESInstituto de Salud Carlos III · ESHospital Doctor José Molina Orosa · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ESInstituto Murciano de Investigación Biosanitaria · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of Next-Generation Sequencing (NGS) has provided useful diagnostic, prognostic, and therapeutic strategies for individualized management of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Consequently, NGS is rapidly being established in clinical practice. However, the technology's complexity, bioinformatics analysis, and the different available options difficult a broad consensus between different laboratories in its daily routine introduction. This collaborative study among Spanish centers was aimed to assess the feasibility, pros, and cons of our customized panel and other commercial alternatives of NGS-targeted approaches. The custom panel was tested in three different sequencing centers. We used the same samples to assess other commercial panels (Oncomine

Indexed as

childhood acute lymphoblastic leukemianext-generation sequencingNGS-targeted panel

Identifiers

PMID33255984
PMCPMC7711852
OpenAlexW3110386498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.