Evidence map›Paper›PMID 33255811›Full record

ArticleMicroorganisms2020

Correlation between Human Papillomavirus Codetection Profiles and Cervical Intraepithelial Neoplasia in Japanese Women.

Kaori Okayama, Hirokazu Kimura, Koji Teruya, Yasuyoshi Ishii, Kiyotaka Fujita, Masahiko Fujii, Mizue Oda, Toshiyuki Sasagawa, Mitsuaki Okodo

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kaori OkayamaDepartment of Medical Technology, Faculty of Health Sciences, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.ORCID 0000-0002-5994-9670
Hirokazu KimuraDepartment of Medical Technology, Faculty of Health Sciences, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.
Koji TeruyaDepartment of Health and Welfare, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi, Tokyo 181-8621, Japan.
Yasuyoshi IshiiGenki Plaza Medical Center for Health Care, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan.
Kiyotaka FujitaDepartment of Medical Technology, Faculty of Health Sciences, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.
Masahiko FujiiDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi, Tokyo 181-8621, Japan.
Mizue OdaGenki Plaza Medical Center for Health Care, 3-6-5 Iidabashi, Chiyoda-ku, Tokyo 102-0072, Japan.
Toshiyuki SasagawaDepartment of Obstetrics and Gynecology, Kanazawa Medical University, 1-1 Uchinadadaigaku, Kahoku-gun, Ishikawa 920-0293, Japan.
Mitsuaki OkodoDepartment of Medical Technology, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi, Tokyo 181-8621, Japan.ORCID 0000-0001-6152-3217
Gumma Paz College · JPKyorin University · JPGenki Plaza Medical Center for Health Care · JPKanazawa Medical University · JP

Funding

Japan Agency for Medical Research and Development JP20fk0108103Japan Society for the Promotion of Science JP26460459
6 · The paper itself

Abstract

Human papillomavirus (HPV) infection is thought to be strongly associated with the precarcinomatous state cervical intraepithelial neoplasia (CIN) and cervical carcinoma. To accurately assess the correlation between HPV detection profiles and CIN, the uniplex E6/E7 polymerase chain reaction (PCR) method was used. We detected HPV (37 genotypes) in 267 CIN cases. The detection of a single high-risk HPV genotype occurred in 69.7% of CIN1 and worse than CIN1 (CIN1+) cases whereas other types were detected in 11.6% of cases. Codetection of high-risk HPV genotypes occurred in 4.9% of CIN1+ cases. The high-risk genotype HPV16 was the most frequently detected genotype in CIN1+ lesions; the genotype HPV34 (not a high-risk type) was detected in some CIN3 cases. Furthermore, HPV codetection may not be associated with CIN grades. These results suggest that various HPV genotypes are associated with CIN across all analyzed cases.

Indexed as

cervical intraepithelial neoplasia (CIN)codetectionhigh-risk human papillomavirus (HPV)human papillomavirus (HPV)invasive cervical cancer (ICC)uniplex E6/E7 PCR method

Identifiers

PMID33255811
PMCPMC7761012
OpenAlexW3108624899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.