Evidence map›Paper›PMID 33255677›Full record

ArticleInternational journal of molecular sciences2020

The Gut-Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing.

Andrea Ticinesi, Leonardo Mancabelli, Sara Tagliaferri, Antonio Nouvenne, Christian Milani, Daniele Del Rio, Fulvio Lauretani, Marcello Giuseppe Maggio, Marco Ventura, Tiziana Meschi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 9 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 9 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
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  10. Heat-treatedJournal of microbiology and biotechnology · 2026
    Trial
  11. Trial
  12. Gut microbiota characteristics in patients with inguinal hernia: a prospective observational study.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Observational
  13. Review
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  15. Intersections of gastrointestinal dysbiosis of the gut microbiome and aging.World journal of gastrointestinal pathophysiology · 2026
    Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrea TicinesiGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.ORCID 0000-0001-9171-8592
Leonardo MancabelliMicrobiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Sara TagliaferriDepartment of Medicine and Surgery, University of Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.ORCID 0000-0002-0468-4863
Antonio NouvenneGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.
Christian MilaniMicrobiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Daniele Del RioDepartment of Medical Veterinary Sciences, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.ORCID 0000-0001-5394-1259
Fulvio LauretaniGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.
Marcello Giuseppe MaggioGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.
Marco VenturaMicrobiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Tiziana MeschiGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.
University of Parma · IT

Funding

University of Parma FIL Quota Incentivante 2016-17
6 · The paper itself

Abstract

The gut microbiota could influence the pathophysiology of age-related sarcopenia through multiple mechanisms implying modulation of chronic inflammation and anabolic resistance. The aim of this study was to compare the fecal microbiota composition and functionality, assessed by shotgun metagenomics sequencing, between two groups of elderly outpatients, differing only for the presence of primary sarcopenia. Five sarcopenic elderly subjects and twelve non-sarcopenic controls, classified according to lower limb function and bioimpedance-derived skeletal muscle index, provided a stool sample, which was analyzed with shotgun metagenomics approaches, to determine the overall microbiota composition, the representation of bacteria at the species level, and the prediction of bacterial genes involved in functional metabolic pathways. Sarcopenic subjects displayed different fecal microbiota compositions at the species level, with significant depletion of two species known for their metabolic capacity of producing short-chain fatty acids (SCFAs),

Indexed as

AgedAged, 80 and overAgingBacteroidetesEubacterialesFaecalibacterium prausnitziiFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeHumansInflammationMaleMetabolic Networks and PathwaysMetagenomeMetagenomicsFatty Acids, Volatilefrailtygeriatricsgut microbiotagut–muscle axisphysical function

Identifiers

PMID33255677
PMCPMC7728056
OpenAlexW3109391513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.