Evidence map›Paper›PMID 33255674›Full record

ArticleInternational journal of molecular sciences2020

Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials.

Izabela Małuch, Oktawian Stachurski, Paulina Kosikowska-Adamus, Marta Makowska, Marta Bauer, Dariusz Wyrzykowski, Aleksandra Hać, Wojciech Kamysz, Milena Deptuła, Michał Pikuła and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Izabela MałuchFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Oktawian StachurskiFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Paulina Kosikowska-AdamusFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.ORCID 0000-0002-4737-2771
Marta MakowskaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Marta BauerFaculty of Pharmacy, Medicinal University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Dariusz WyrzykowskiFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Aleksandra HaćFaculty of Biology, University of Gdansk, Str. 59, 80-308 Gdansk, Poland.ORCID 0000-0002-0478-3263
Wojciech KamyszFaculty of Pharmacy, Medicinal University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Milena DeptułaLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Faculty of Medicine, Medical University of Gdansk, Dębinki 1, 80-211 Gdańsk, Poland.ORCID 0000-0003-4875-770X
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Faculty of Medicine, Medical University of Gdansk, Dębinki 1, 80-211 Gdańsk, Poland.ORCID 0000-0001-7751-9781
Emilia SikorskaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
University of Gdańsk · PLGdańsk Medical University · PL

Funding

Narodowe Centrum Nauki 2016/21/B/ST5/01375
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by lipidation. This study focuses on the newly designed and synthesized lipopeptides containing multiple Lys residues or their shorter homologues with palmitic acid (C

Indexed as

Amino Acid SequenceAntimicrobial Cationic PeptidesBacterial InfectionsCandida albicansEscherichia coliHumansLipopeptidesMicrobial Sensitivity TestsMycosesStructure-Activity RelationshipAntimicrobial Cationic PeptidesLipopeptidesantimicrobial agentcationic lipopeptidedouble-headed lipopeptidepeptide-lipid conjugateself-assembly

Identifiers

PMID33255674
PMCPMC7728077
OpenAlexW3108853030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.