Evidence map›Paper›PMID 33255644›Full record

ReviewInternational journal of molecular sciences2020

From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies.

Mónika Sztretye, László Szabó, Nóra Dobrosi, János Fodor, Péter Szentesi, János Almássy, Zsuzsanna É Magyar, Beatrix Dienes, László Csernoch

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Frontiers in neurology
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mónika SztretyeDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0002-5946-6986
László SzabóDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Nóra DobrosiDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
János FodorDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Péter SzentesiDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
János AlmássyDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Zsuzsanna É MagyarDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Beatrix DienesDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0002-3110-0296
László CsernochDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0002-2446-1456
University of Debrecen · HU

Funding

Hungarian National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00044Ministry for Innovation and Technology in Hungary ED_18-1-2019-0028Nemzeti Kutatási Fejlesztési és Innovációs Hivatal PD-128370
6 · The paper itself

Abstract

Muscular dystrophies are a group of more than 160 different human neuromuscular disorders characterized by a progressive deterioration of muscle mass and strength. The causes, symptoms, age of onset, severity, and progression vary depending on the exact time point of diagnosis and the entity. Congenital myopathies are rare muscle diseases mostly present at birth that result from genetic defects. There are no known cures for congenital myopathies; however, recent advances in gene therapy are promising tools in providing treatment. This review gives an overview of the mouse models used to investigate the most common muscular dystrophies and congenital myopathies with emphasis on their potentials and limitations in respect to human applications.

Indexed as

Genetic TherapyAnimalsDisease Models, AnimalDisease ProgressionHumansMiceMice, TransgenicMuscular DystrophiesMyopathies, Structural, Congenitaldystrophinopathiesdystrophymalignant hyperthermiamouse modelsmuscle disordersmyopathy

Identifiers

PMID33255644
PMCPMC7728138
OpenAlexW3107943267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.