Evidence map›Paper›PMID 33255633›Full record

ReviewBrain sciences2020

Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology.

Andrea Becchetti, Laura Clara Grandi, Giulia Colombo, Simone Meneghini, Alida Amadeo

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Cys-loop receptors on cannabinoids: All high?Frontiers in physiology · 2022
    Pooled it
  2. Essential Oils: Chemistry and Mechanisms of Anticonvulsant Action.International journal of molecular sciences · 2026
    Review
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  7. NovelFrontiers in neuroscience · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrea BecchettiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.ORCID 0000-0002-9297-0527
Laura Clara GrandiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.ORCID 0000-0001-8174-5394
Giulia ColomboDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.ORCID 0000-0001-7704-7446
Simone MeneghiniDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.
Alida AmadeoDepartment of Biosciences, University of Milano, 20133 Milano, Italy.
University of Milano-Bicocca · ITUniversity of Milan · IT

Funding

University of Milano-Bicocca 2019-ATESP-0029
6 · The paper itself

Abstract

Sleep-related hypermotor epilepsy (SHE) is characterized by hyperkinetic focal seizures, mainly arising in the neocortex during non-rapid eye movements (NREM) sleep. The familial form is autosomal dominant SHE (ADSHE), which can be caused by mutations in genes encoding subunits of the neuronal nicotinic acetylcholine receptor (nAChR), Na

Indexed as

antiepilepticautosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)autosomal dominant sleep-related hypermotor epilepsy (ADSHE)cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)cholinergic receptor nicotinic alpha 4 subunit (CHRNA4)cholinergic receptor nicotinic beta 2 subunit (CHRNB2)K+-Cl− cotransporter type 2 (KCC2)neuronal nicotinic acetylcholine receptor (nAChR)synaptogenesis

Identifiers

PMID33255633
PMCPMC7761363
OpenAlexW3108246983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.