Evidence map›Paper›PMID 33255564›Full record

ArticlePharmaceutics2020

Optimization of Liposomes for Antigen Targeting to Splenic CD169

Maarten K Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F van Nostrum, Yvette van Kooyk, Gert Storm and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Exploring CD169Vaccines · 2025
    Review
  6. Recent Advances of Trained immunity in Macrophages.International journal of biological sciences · 2025
    Review
  7. Exosomes secreted by ST3GAL5Molecular oncology · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Targeting of sialoadhesin-expressing macrophages through antibody-conjugated (polyethylene glycol) poly(lactic-co-glycolic acid) nanoparticles.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022
    Article
  12. Article
  13. Review
  14. Siglec Ligands.Cells · 2021
    Review
  15. Article
  16. CD169 Defines Activated CD14Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maarten K Nijen TwilhaarDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Lucas CzentnerDepartment of Pharmaceutics, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Joanna GrabowskaDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Alsya J AffandiDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.ORCID 0000-0003-0859-2322
Chun Yin Jerry LauDepartment of Pharmaceutics, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-2079-208X
Katarzyna OlesekDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Hakan KalayDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Cornelus F van NostrumDepartment of Pharmaceutics, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Yvette van KooykDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Gert StormDepartment of Pharmaceutics, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Joke M M den HaanDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.ORCID 0000-0002-4421-6917
Vrije Universiteit Amsterdam · NLUtrecht University · NL

Funding

KWF Kankerbestrijding VU2016-10449Phospholipid Research Center PRC 20012020ZonMw TOP 91218024
6 · The paper itself

Abstract

Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture particulate antigens from the blood and transfer these antigens to dendritic cells for the activation of CD8

Indexed as

cancer vaccinationCD169GM3liposomemacrophagesialoadhesinSiglec-1targetingT cells

Identifiers

PMID33255564
PMCPMC7760819
OpenAlexW3107700070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.