Evidence map›Paper›PMID 33255506›Full record

ArticleInternational journal of molecular sciences2020

Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.

Jonas Ort, Benedikt Kremer, Linda Grüßer, Romy Blaumeiser-Debarry, Hans Clusmann, Mark Coburn, Anke Höllig, Ute Lindauer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Neuroprotection: Rescue from Neuronal Death in the Brain.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jonas OrtDepartment of Neurosurgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Benedikt KremerDepartment of Neurosurgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Linda GrüßerDepartment of Anaesthesiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Romy Blaumeiser-DebarryDepartment of Anaesthesiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Hans ClusmannDepartment of Neurosurgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Mark CoburnDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.
Anke HölligDepartment of Neurosurgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-6798-5703
Ute LindauerDepartment of Neurosurgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-3781-4169
RWTH Aachen University · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective pharmacological neuroprotection is one of the most desired aims in modern medicine. We postulated that a combination of two clinically used drugs-nimodipine (L-Type voltage-gated calcium channel blocker) and amiloride (acid-sensing ion channel inhibitor)-might act synergistically in an experimental model of ischaemia, targeting the intracellular rise in calcium as a pathway in neuronal cell death. We used organotypic hippocampal slices of mice pups and a well-established regimen of oxygen-glucose deprivation (OGD) to assess a possible neuroprotective effect. Neither nimodipine (at 10 or 20 µM) alone or in combination with amiloride (at 100 µM) showed any amelioration. Dissolved at 2.0 Vol.% dimethyl-sulfoxide (DMSO), the combination of both components even increased cell damage (

Indexed as

Acid Sensing Ion ChannelsAmilorideAnimalsBrain IschemiaCalcium Channels, L-TypeCells, CulturedGlucoseHippocampusHumansMiceNeuronsNeuroprotective AgentsNimodipineOxygenAcid Sensing Ion ChannelsAmilorideASIC1 protein, mouseCalcium Channels, L-TypeGlucoseNeuroprotective AgentsNimodipineOxygenacid-sensing ion channelsamilorideneural injuryneuroprotectionnimodipineoxygen-glucose deprivationsubarachnoid haemorrhage

Identifiers

PMID33255506
PMCPMC7727815
OpenAlexW3106973936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.