Evidence map›Paper›PMID 33255425›Full record

ArticleCancers2020

Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naïve Patients with Resectable Non-Small-Cell Lung Cancer.

Seyer Safi, Yoshikane Yamauchi, Hans Hoffmann, Wilko Weichert, Philipp J Jost, Hauke Winter, Thomas Muley, Philipp Beckhove

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02515760 naactive not recruitingnot on this map

Tumor-specific Effector T Cells in Non-small Cell Lung Cancer

TypeinterventionalSponsorUniversity Hospital HeidelbergRan2014 to 2025Enrolled120ConditionsNon-small Cell Lung CancerArmsBone marrow aspiration from the iliac crest, Illinois bone marrow aspiration neddle
NCT05982574 active not recruitingnot on this map

Tumor Microenvironment in Lung Adenocarcinoma

TypeobservationalSponsorUniversity Hospital HeidelbergRan2016 to 2026Enrolled300ConditionsLung Adenocarcinoma
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Seyer SafiDivision of Thoracic Surgery, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany.
Yoshikane YamauchiDepartment of Surgery, Teikyo University School of Medicine, Tokyo 173-8605, Japan.ORCID 0000-0002-3374-2399
Hans HoffmannDivision of Thoracic Surgery, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany.
Wilko WeichertInstitute of Pathology, Technical University of Munich, Trogerstrasse 18, 81675 Munich, Germany.
Philipp J JostMedical Department III for Hematology and Oncology, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany.
Hauke WinterDepartment of Thoracic Surgery, Thoraxklinik, Heidelberg University Hospital, Roentgenstrasse 1, 69126 Heidelberg, Germany.
Thomas MuleyTranslational Lung Research Center (TLRC), Member of German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Philipp BeckhoveRegensburg Center for Interventional Immunology and Regensburg University Hospital, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Heidelberg University · DETUM Klinikum · DEGerman Cancer Research Center · DETechnical University of Munich · DETeikyo University · JPUniversity Hospital Regensburg · DE

Funding

Else-Kröner-Fresenius Stiftung, Bad-Homburg, Germany 2016_A170
6 · The paper itself

Abstract

Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines in the peripheral blood and tumor tissues from treatment-naïve patients with NSCLC (

Indexed as

cytokineimmunotherapylung cancerT cells

Identifiers

PMID33255425
PMCPMC7761081
OpenAlexW3108458483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.