Evidence map›Paper›PMID 33255375›Full record

ArticleVaccines2020

Comprehensive Evaluation of Immune-Checkpoint DNA Cancer Vaccines in a Rat Cholangiocarcinoma Model.

Yi-Ru Pan, Chiao-En Wu, Ming-Huang Chen, Wen-Kuan Huang, Hsuan-Jen Shih, Keng-Li Lan, Chun-Nan Yeh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Advances in Targeted Immunotherapy for Hepatobiliary Cancers.International journal of molecular sciences · 2022
    Review
  4. Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research.Journal of clinical and translational hepatology · 2022
    Review
  5. The role of tumor-infiltrating lymphocytes in cholangiocarcinoma.Journal of experimental & clinical cancer research : CR · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yi-Ru PanDepartment of General Surgery and Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0001-5812-2674
Chiao-En WuDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.ORCID 0000-0002-1081-8805
Ming-Huang ChenCenter for Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Wen-Kuan HuangDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.ORCID 0000-0001-7789-8347
Hsuan-Jen ShihDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Keng-Li LanDepartment of Oncology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Chun-Nan YehDepartment of General Surgery and Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Chang Gung University, Taoyuan 333, Taiwan.
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWKarolinska University Hospital · SE

Funding

Ministry of Science and Technology, Taiwan 108-2314-B-182A-007 to CEWundefined <span style="color:gray;font-size:10px;">undefined</span> CMRPG3I0231, CMRPG3I0241~2, CORPG3J0251~2, CRRPG3K0011 CRRPG3K0031 and CMRPG3K0711 to CNY, NMRPG3J0011 and CRRPG3K0021 to CEW and CMRPG3K0601 to HJS
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a malignant tumor with aggressive biological behavior. Immune checkpoints such as cytotoxic T-lymphocyte antigen 4 (CTLA4) and antiprogrammed death 1 (PD-1) are critical immune-checkpoint molecules that repress T-cell activation. The DNA

Indexed as

cholangiocarcinomaCTLA4DNA vaccinePD-1PD-L1

Identifiers

PMID33255375
PMCPMC7712087
OpenAlexW3107880452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.