Evidence map›Paper›PMID 33255267›Full record

ArticleCancers2020

Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma.

Andrew B Gill, Leonardo Rundo, Jonathan C M Wan, Doreen Lau, Jeries P Zawaideh, Ramona Woitek, Fulvio Zaccagna, Lucian Beer, Davina Gale, Evis Sala and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  11. Tumour burden and efficacy of immune-checkpoint inhibitors.Nature reviews. Clinical oncology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Andrew B GillDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-9287-9563
Leonardo RundoDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3341-5483
Jonathan C M WanCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.ORCID 0000-0003-0001-1802
Doreen LauDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Jeries P ZawaidehDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Ramona WoitekDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Fulvio ZaccagnaDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Lucian BeerDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Davina GaleCancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Evis SalaDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Dominique-Laurent CouturierCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.
Pippa G CorrieDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Nitzan RosenfeldCancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

Austrian Science Fund FWF J 4025Cancer Research UK 11906Cancer Research UK 16628Cancer Research UK 27150Cancer Research UK 27548Cancer Research UK 28292Cancer Research UK C19212/A27150, C19212/A16628
6 · The paper itself

Abstract

Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and specific biomarker for response monitoring. Here we evaluated the interrelationship between circulating tumor DNA mutant allele fraction (ctDNA

Indexed as

circulating tumor DNAliquid biopsyradiomicstumor heterogeneitytumor imaging

Identifiers

PMID33255267
PMCPMC7759931
OpenAlexW3106752770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.