Evidence map›Paper›PMID 33255265›Full record

ArticleGenes2020

Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases.

Viktor Hlavac, Beatrice Mohelnikova-Duchonova, Martin Lovecek, Jiri Ehrmann, Veronika Brynychova, Katerina Kolarova, Pavel Soucek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Viktor HlavacBiomedical Center, Faculty of Medicine in Pilsen, Charles University, 306 05 Pilsen, Czech Republic.ORCID 0000-0003-0695-0552
Beatrice Mohelnikova-DuchonovaDepartment of Oncology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Martin LovecekDepartment of Surgery I, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.ORCID 0000-0001-9775-9643
Jiri EhrmannDepartment of Clinical and Molecular Pathology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Veronika BrynychovaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, 306 05 Pilsen, Czech Republic.
Katerina KolarovaDepartment of Oncology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.ORCID 0000-0002-8201-171X
Pavel SoucekBiomedical Center, Faculty of Medicine in Pilsen, Charles University, 306 05 Pilsen, Czech Republic.ORCID 0000-0002-4294-6799
Charles University · CZInstitute of Molecular and Translational Medicine · CZUniversity Hospital Olomouc · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutation spectra of 250 cancer driver, druggable, and actionable genes were analyzed in surgically resected pancreatic ductal adenocarcinoma (PDAC) patients who developed metachronous pulmonary metastases. Targeted sequencing was performed in DNA from blood and archival samples of 15 primary tumors and three paired metastases. Results were complemented with the determination of G12V mutation in

Indexed as

AdenocarcinomaFemaleFilaggrin ProteinsGene FrequencyHumansLung NeoplasmsMaleMiddle AgedMutationPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)S100 ProteinsTumor Suppressor Protein p53Filaggrin ProteinsFLG2 protein, humanProto-Oncogene Proteins p21(ras)S100 ProteinsTumor Suppressor Protein p53adenocarcinomametastasesnext-generation sequencingpancreaspulmonarysurvival

Identifiers

PMID33255265
PMCPMC7760784
OpenAlexW3107767309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.