Evidence map›Paper›PMID 33255261›Full record

ArticleToxins2020

Receptor Binding Domains of TcdB from

Daniel Henkel, Helma Tatge, Dennis Schöttelndreier, Liang Tao, Min Dong, Ralf Gerhard

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Mechanisms ofFrontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. International journal of molecular sciences · 2023
    Review
  8. A leaky human colon model reveals uncoupled apical/basal cytotoxicity in earlyAmerican journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  9. Neutralising Effects of Different Antibodies onInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Cytotoxic synergism ofWorld journal of gastroenterology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Invisible steps for a global endemy: molecular strategies adopted byTherapeutic advances in gastroenterology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Daniel HenkelInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Helma TatgeInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Dennis SchöttelndreierInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Liang TaoDepartment of Urology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-3441-698X
Min DongDepartment of Urology, Boston Children's Hospital, Boston, MA 02115, USA.
Ralf GerhardInstitute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DEBoston Children's Hospital · US

Funding

Deutsche Forschungsgemeinschaft GE 1017/6-1National Natural Science Foundation of China 31970129 and 31800128Natural Science Foundation of Zhejiang Province . LR20C010001Niedersächsisches Ministerium für Wissenschaft und Kultur Niedersächsisches Vorab VWZN3380
6 · The paper itself

Abstract

Toxin B (TcdB) produced by

Indexed as

Amino Acid SubstitutionBacterial ProteinsBacterial ToxinsCell LineChondroitin Sulfate Proteoglycan 4Chondroitin Sulfate ProteoglycansClostridioides difficileFrizzled ReceptorsGene Knockdown TechniquesHeLa CellsHumansMembrane ProteinsMutagenesis, Site-DirectedProtein BindingProtein Interaction Domains and MotifsVirulence FactorsBacterial ProteinsBacterial ToxinsChondroitin Sulfate Proteoglycan 4Chondroitin Sulfate ProteoglycansCSPG4 protein, humanFrizzled ReceptorsMembrane ProteinstoxB protein, Clostridium difficileVirulence FactorsClostridioides difficileglucosyltransferasereceptor binding

Identifiers

PMID33255261
PMCPMC7759879
OpenAlexW3108634616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.