Evidence map›Paper›PMID 33254591›Full record

ArticleMedical hypotheses2020

Should an intersection between visceral leishmaniasis endemicity and the COVID-19 pandemic be considered?

Sílvio Fernando Guimarães Carvalho, Thallyta Maria Vieira, Ana Paula Venuto Moura, Marileia Chaves Andrade

Open access · greenAbstract readLetter
In one paragraph

Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. The Impact of COVID-19 Pandemic on Arthropod-Related Diseases.Journal of arthropod-borne diseases · 2023
    Review
  3. Review
  4. Severe visceral leishmaniasis and COVID-19 coinfection in an immunosuppressed patient.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sílvio Fernando Guimarães CarvalhoUniversidade Estadual de Montes Claros, UNIMONTES, Montes Claros, Minas Gerais, Brazil; Centro de Pesquisas em Doenças Infecciosas e Parasitárias, Brazil.
Thallyta Maria VieiraUniversidade Estadual de Montes Claros, UNIMONTES, Montes Claros, Minas Gerais, Brazil; Centro de Pesquisas em Doenças Infecciosas e Parasitárias, Brazil.
Ana Paula Venuto MouraUniversidade Estadual de Montes Claros, UNIMONTES, Montes Claros, Minas Gerais, Brazil; Centro de Pesquisas em Doenças Infecciosas e Parasitárias, Brazil.
Marileia Chaves AndradeUniversidade Estadual de Montes Claros, UNIMONTES, Montes Claros, Minas Gerais, Brazil; Centro de Pesquisas em Doenças Infecciosas e Parasitárias, Brazil. Electronic address: marileia.andrade@unimontes.br.
Universidade Estadual de Montes Claros · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic caused by the infection with the novel Coronavirus SARS-CoV-2, revealed individual and global vulnerabilities, in which we highlight the social, economic, and political aspects and the health systems' organization in the countries. Brazil remains with a high transmission rate and presents a centripetal distribution as observed through a more sustained growth in the number of municipalities affected, outlining a profile of invasion of poor communities. Several vulnerabilities overlap with precarious housing conditions, lack of basic sanitation, malnutrition, and endemicity for neglected chronic diseases such as visceral leishmaniasis (VL). COVID-19 and VL evidently do not share clinical features, but exactly because of the distinct immunopathogenesis between the diseases, patients with VL may present a vulnerability in the immune system against antiviral responses. Considering that VL susceptibility seems to be related to an inefficient and polarized immune response, it is likely that in endemic areas, the overlap of social weaknesses added to individual vulnerability by immune polarization may aggravate the COVID-19 condition. In this sense, we reinforce that possible relationships between endemic neglected diseases such as VL and pandemic SARS-CoV-2 infection need to be further considered and investigated.

Indexed as

ComorbidityCOVID-19Global HealthHumansImmune SystemInterferon-gammaLeishmaniasis, VisceralPandemicsVulnerable PopulationsInterferon-gammaBrazilCOVID-19Immune responseSARS-CoV-2Visceral leishmaniasis

Identifiers

PMID33254591
PMCPMC7501079
OpenAlexW3087604282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.