ArticleMedical hypotheses2020
The influence of ABO blood groups on COVID-19 susceptibility and severity: A molecular hypothesis based on carbohydrate-carbohydrate interactions.
Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Investigating ABO Blood Groups and Secretor Status in Relation to SARS-CoV-2 Infection and COVID-19 Severity.Journal of personalized medicine · 2024Review
- Association Between ABO Blood Group System and COVID-19 Severity.American journal of clinical pathology · 2022Article
- When the clock ticks wrong with COVID-19.Clinical and translational medicine · 2022Review
- Cross-GWAS coherence test at the gene and pathway level.PLoS computational biology · 2022Article
- ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanisms.Microbial pathogenesis · 2022Review
- Impact of ABO and Rhesus blood groups on COVID-19 susceptibility and severity: A case-control study.Journal of medical virology · 2022Article
- A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody.International journal of molecular sciences · 2022Review
- COVID-19, Cation Dysmetabolism, Sialic Acid, CD147, ACE2, Viroporins, Hepcidin and Ferroptosis: A Possible Unifying Hypothesis.F1000Research · 2022Review
- Effects of ABO blood groups and RH-factor on COVID-19 transmission, course and outcome: A review.Frontiers in medicine · 2022Review
- Host polymorphisms and COVID-19 infection.Advances in clinical chemistry · 2022Article
- Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2021Article
- A comprehensive review of COVID-19 biology, diagnostics, therapeutics, and disease impacting the central nervous system.Journal of neurovirology · 2021Review
- Catch Me if You Can: Superspreading of COVID-19.Trends in microbiology · 2021Review
- Association between blood groups and COVID-19 outcome in Iranian patients.Future virology · 2021Article
- The trans-omics landscape of COVID-19.Nature communications · 2021Article
- ABO phenotype and SARS-CoV-2 infection: Is there any correlation?Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Review
- Association between ABO blood types and coronavirus disease 2019 (COVID-19), genetic associations, and underlying molecular mechanisms: a literature review of 23 studies.Annals of hematology · 2021Review
- Current understanding of the influence of environmental factors on SARS-CoV-2 transmission, persistence, and infectivity.Environmental science and pollution research international · 2021Review
- COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine.Mayo Clinic proceedings · 2021Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world is experiencing one of the most difficult moments in history with the COVID-19 pandemic, a disease caused by SARS-CoV-2, a new type of coronavirus. Virus infectivity is mediated by the binding of Spike transmembrane glycoprotein to specific protein receptors present on cell host surface. Spike is a homotrimer that emerges from the virion, each monomer containing two subunits named S1 and S2, which are related to cell recognition and membrane fusion, respectively. S1 is subdivided in domains S1A (or NTD) and S1B (or RBD), with experimental and in silico studies suggesting that the former binds to sialic acid-containing glycoproteins, such as CD147, whereas the latter binds to ACE2 receptor. Recent findings indicate that the ABO blood system modulates susceptibility and progression of infection, with type-A individuals being more susceptible to infection and/or manifestation of a severe condition. Seeking to understand the molecular mechanisms underlying this susceptibility, we carried out an extensive bibliographic survey on the subject. Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell. This model could explain previous sparse observations on the molecular mechanism of infection and can direct future research to better understand of COVID-19 pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.