SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020
Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review.
Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis.European journal of neurology · 2021Pooled it
- A case-based systematic review on the SARS-COVID-2-associated cerebrovascular diseases and the possible virus routes of entry.Journal of neurovirology · 2021Pooled it
- Sex Differences and Clinical Outcomes of Patients with Coronavirus Disease 2019 Infection and Cerebral Venous Sinus Thrombosis: A Systematic Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications.European cytokine network · 2026Review
- Reversible cerebral vasoconstriction syndrome in psychiatric settings: Context-dependent diagnostic bias and consultation-liaison psychiatry practice.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Risk of Venous Thromboembolism in Infectious Diseases: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Association Between Thyrotoxicosis and Cerebral Venous Thrombosis.Journal of clinical medicine · 2024Review
- Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke.Frontiers of medicine · 2023Review
- Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers.CNS neuroscience & therapeutics · 2023Review
- Post-COVID symptom profiles and duration in a global convalescent COVID-19 observational cohort: Correlations with demographics, medical history, acute COVID-19 severity and global region.Journal of global health · 2023Observational
- A Literature Review of Pathophysiology, Clinical Manifestations, Medications and Optimal Dosage, Outpatient, and Post-hospitalization Use of Anticoagulation in COVID-19 Patients.Anatolian journal of cardiology · 2023Review
- A review of the potential neurological adverse events of COVID-19 vaccines.Acta neurologica Belgica · 2023Review
- Sagittal sinus thrombosis with subarachnoid haemorrhage in a patient with COVID-19 infection.BMJ case reports · 2023Article
- The Burden of Cerebral Venous Thrombosis in a Romanian Population across a 5-Year Period.Life (Basel, Switzerland) · 2022Article
- The Outcomes of COVID-19 Patients with Spontaneous Intracerebral Hemorrhage Comorbidity and the Efficacy of Enoxaparin in Decreasing the Mortality Rate in Them: Single Egyptian Center Report.Journal of personalized medicine · 2022Article
- Article
- MRI-negative myelitis associated with cerebral venous thrombosis after COVID-19 infection.BMJ case reports · 2022Article
- Neuro-ophthalmic Sequelae in COVID-19 Recovered Cases.Indian journal of ophthalmology · 2022Article
- Case report: Cerebral sinus thrombosis as a complication of COVID-19.Visual journal of emergency medicine · 2022Article
- Reprint of: Cerebral venous thrombosis in a young patient with COVID-19.Disease-a-month : DM · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been increasing reports associating the coronavirus disease 2019 (COVID-19) with thromboembolic phenomenon including ischemic strokes and venous thromboembolism. Cerebral venous thrombosis (CVT) is a rare neurovascular emergency that has been observed in some COVID-19 patients, yet much remains to be learnt of its underlying pathophysiology.
objectiveWe present a case series of local patients with concomitant COVID-19 infection and CVT; and aim to perform a systematic review of known cases in the current literature.
methodsWe describe two patients with concomitant COVID-19 infection and CVT from a nationwide registry in Singapore. We then conducted a literature search in PubMed and Embase using a suitable keyword search strategy from 1st December 2019 to 11th June 2020. All studies reporting CVT in COVID-19 patients were included.
resultsNine studies and 14 COVID-19 patients with CVT were studied. The median age was 43 years (IQR=36-58) and majority had no significant past medical conditions (60.0%). The time taken from onset of COVID-19 symptoms to CVT diagnosis was a median of 7 days (IQR=6-14). CVT was commonly seen in the transverse (75.0%) and sigmoid sinus (50.0%); 33.3% had involvement of the deep venous sinus system. A significant proportion of patients had raised D-dimer (75.0%) and CRP levels (50.0%). Two patients reported presence of antiphospholipid antibodies. Most patients received anticoagulation (91.7%) while overall mortality rate was 45.5%.
conclusionsThe high mortality rate of CVT in COVID-19 infection warrants a high index of suspicion from physicians, and early treatment with anticoagulation should be initiated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.