ArticleThe Journal of antimicrobial chemotherapy2021
Characterization and outcome of invasive infections due to Paecilomyces variotii: analysis of patients from the FungiScope® registry and literature reports.
Article in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry.The Journal of antimicrobial chemotherapy · 2022Pooled it
- Therapeutic Failure in Invasive Fungal Infections: Beyond Antifungal Resistance-A Narrative Review.Journal of fungi (Basel, Switzerland) · 2026Review
- 30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2026Review
- A hospital-based retrospective study of hospitalizations with hyalohyphomycosis and phaeohyphomycosis in the United States.Lancet regional health. Americas · 2026Article
- AggressiveJournal of fungi (Basel, Switzerland) · 2025Article
- Microfungi associated with dying quiver trees (Fungal systematics and evolution · 2025Article
- Beyond the Ear, the Hidden Threat of Paecilomyces Neuro-Otological Infection: A Case Report.The journal of international advanced otology · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Severe pneumonia with pleural effusion caused by co-infection of Paecilomyces variotii and Penicillium oxalicum in a diabetic patient.BMC infectious diseases · 2024Article
- Article
- Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.Clinical microbiology reviews · 2023Review
- Case Report: Cutaneous Mycosis Caused by Purpureocillium lilacinum.The American journal of tropical medicine and hygiene · 2023Article
- A Polyphasic Approach including Whole Genome Sequencing RevealsJournal of fungi (Basel, Switzerland) · 2023Article
- Non-Journal of fungi (Basel, Switzerland) · 2023Review
- Characterization and expression of fungal defensin inFrontiers in microbiology · 2023Article
- Article
- Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species.Medical mycology · 2022Article
- Paecilomyces variotti in deep dental caries.Journal of clinical and experimental dentistry · 2022Article
- Article
- Species Identification and In Vitro Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo provide a basis for clinical management decisions in Paecilomyces variotii infection.
methodsUnpublished cases of invasive P. variotii infection from the FungiScope® registry and all cases reported in the literature were analysed.
resultsWe identified 59 cases with P. variotii infection. Main baseline factors were presence of indwelling devices in 29 cases (49.2%), particularly peritoneal catheters (33.9%) and prosthetic heart valves (10.2%), haematological or oncological diseases in 19 (32.2%), major surgery in 11 (18.6%), and diabetes mellitus in 10 cases (16.9%). The most prevalent infection sites were peritoneum (n = 20, 33.3%) and lungs (n = 16, 27.1%). Pain and fever were frequent (n = 35, 59.3% and n = 33, 55.9%, respectively). Diagnosis was established by culture in 58 cases (98.3%). P. variotii caused breakthrough infection in 8 patients. Systemic antifungals were given in 52 patients (88.1%). Amphotericin B was administered in 39, itraconazole in 15, and posaconazole in 8 patients. Clinical isolates were frequently resistant to voriconazole, whereas the above-mentioned antifungals showed good in vitro activity. Infections of the blood and CNS caused high mortality. Overall mortality was 28.8% and death was attributed to P. variotii in 10 cases.
conclusionsP. variotii causes life-threatening infections, especially in immunocompromised and critically ill patients with indwelling devices. Patients undergoing peritoneal dialysis are at particular risk. Multidisciplinary management is paramount, including molecular techniques for diagnosis and treatment with efficacious systemic antifungals. Amphotericin B, itraconazole and posaconazole are regarded as treatments of choice. Combination with flucytosine may be considered. Surgical debridement and removal of indwelling devices facilitate favourable outcome.
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