ArticleDevelopmental cognitive neuroscience2021
Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior.
Article in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Validation of the Clinical Assessment of Prosocial Emotions (CAPE) and Subtype Differentiation of Callous-Unemotional Traits in Children and Adolescents: A Study Protocol.Behavioral sciences (Basel, Switzerland) · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits.Biomedicines · 2025Review
- You are a Mirror of My Childhood: Pathways Through Family Dyadic Interactions and Gender Preference in the Intergenerational Association of ODD Symptoms.Research on child and adolescent psychopathology · 2025Article
- Sex-specific grey matter abnormalities in individuals with chronic insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Sex dimorphic cortical brain volumes associated with antisocial behavior in young adults.Psychoradiology · 2023Article
- Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors.NeuroImage. Clinical · 2023Article
- Amygdala-prefrontal connectivity in children with maladaptive aggression is modulated by social impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.Social cognitive and affective neuroscience · 2022Article
- Executive Functions and Juvenile Delinquency: A Comparative Analysis of Institutionalized Adolescents in Colombia.International journal of psychological researchArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sex differences in brain structure in children with disruptive behavior disorders (DBD) remain poorly understood. This study examined sex differences in gray matter volume in children with DBD in a priori regions-of-interest implicated in the pathophysiology of disruptive behavior. We then conducted a whole-brain analysis of cortical thickness to examine sex differences in regions not included in our hypothesis. Exploratory analyses investigated unique associations between structure, and dimensional measures of severity of disruptive behavior and callous-unemotional traits. This cross-sectional study included 88 children with DBD (30 females) aged 8-16 years and 50 healthy controls (20 females). Structural MRI data were analyzed using surface-based morphometry to test for interactions between sex and group. Multiple-regression analyses tested for sex-specific associations between structure, callous-unemotional traits, and disruptive behavior severity. Boys with DBD showed reduced gray matter volume in the left ventromedial prefrontal cortex (vmPFC) and reduced cortical thickness in the supramarginal gyrus, but not girls compared to respective controls. Dimensional analyses revealed associations between sex, callous-unemotional traits, and disruptive behavior for amygdala and vmPFC volume, and ventrolateral prefrontal cortex cortical thickness. Sex-specific differences in prefrontal structures involved in emotion regulation may support identification of neural biomarkers of disruptive behavior to inform target-based treatments.
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