ArticleAnnals of epidemiology2021
Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study.
Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between birth location and short-term outcomes for babies with gastroschisis, congenital diaphragmatic hernia and oesophageal fistula: a systematic review.BMJ paediatrics open · 2023Pooled it
- Analysis of early neonatal case fatality rate among newborns with congenital hydrocephalus, a 2000-2014 multi-country registry-based study.Birth defects research · 2022Pooled it
- Ventricular function in congenital diaphragmatic hernia: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Clinical characteristics and outcomes of congenital diaphragmatic hernia (CDH) in neonates in an Australian neonatal intensive care unit network: a population-based cohort study.BMJ paediatrics open · 2026Article
- NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Preliminary Report of a Nationwide Prospective Cohort of Congenital Diaphragmatic Hernia in Korea.Journal of Korean medical science · 2026Article
- Risk factors for 30-day mortality following major neonatal surgery: insights from a 10-year cohort in southern Tunisia.Surgery today · 2026Article
- Readmission and Late Mortality Among Children With Congenital Diaphragmatic Hernia.JAMA network open · 2026Article
- Echocardiographic predictors of adverse outcomes in infants with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prenatal diagnosis of congenital diaphragmatic hernia with mosaicism of chromosomes 17q and 18q in Iran: a case report.Journal of medical case reports · 2026Article
- Intrathoracic Kidney Associated with Congenital Diaphragmatic Hernia: Prenatal Detection and Outcomes.Fetal diagnosis and therapy · 2026Article
- The factors influencing parents and clinicians in medical decision making for fetuses with congenital diaphragmatic hernia at a tertiary referral centre in Beijing: a five-year retrospective study.BMC pregnancy and childbirth · 2026Article
- Mechanical compression causes lung hypoplasia in congenital diaphragmatic hernia with GATA4 genetic variants.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Risk Stratification of Long-Term Mortality in Infants with Congenital Diaphragmatic Hernia Using the National Health Insurance Service (NHIS) Data.Children (Basel, Switzerland) · 2026Article
- WNT4 deficiency impacts heart, diaphragm, and palate development: Insights from human genetics, machine learning, and mouse models.Developmental biology · 2026Article
- Nationwide Danish Register Based Study Showed a Stable Prevalence of Congenital Diaphragmatic Hernias From 1994 to 2021 but a Decrease in Syndromic Cases.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study.The Lancet. Digital health · 2025Article
- Clinical characteristics and outcomes of neonates with congenital diaphragmatic hernia at the Vietnam National Children's Hospital: a retrospective observational study.BMC pediatrics · 2025Observational
- The Impact of Race and Ethnicity on Congenital Diaphragmatic Hernia 1-Year Mortality.Pediatric pulmonology · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
31 authors.
Funding
Abstract
purposeThis study determined the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH).
methodsTwenty-five hospital- and population-based surveillance programs in 19 International Clearinghouse for Birth Defects Surveillance and Research member countries provided birth defects mortality data between 1974 and 2015. CDH cases included live births, stillbirths, or elective termination of pregnancy for fetal anomalies. Prevalence, cumulative mortality rates, and 95% confidence intervals (CIs) were calculated using Poisson regression and a Kaplan-Meier product-limit method. Joinpoint regression analyses were conducted to assess time trends.
resultsThe prevalence of CDH was 2.6 per 10,000 total births (95% CI: 2.5-2.7), slightly increasing between 2001 and 2012 (average annual percent change = 0.5%; 95% CI:-0.6 to 1.6). The total percent mortality of CDH was 37.7%, with hospital-based registries having more deaths among live births than population-based registries (45.1% vs. 33.8%). Mortality rates decreased over time (average annual percent change = -2.4%; 95% CI: -3.8 to 1.1). Most deaths due to CDH occurred among 2- to 6-day-old infants for both registry types (36.3%, hospital-based; 12.1%, population-based).
conclusionsThe mortality of CDH has decreased over time. Mortality remains high during the first week and varied by registry type.
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