ArticleOsteoarthritis and cartilage2021
Metabolic osteoarthritis - relation of diabetes and cardiovascular disease with knee osteoarthritis.
Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of Warming Needle Moxibustion and Drug Therapy for Treating Knee Osteoarthritis: A Systematic Review and Meta-analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study.The Korean journal of internal medicine · 2026Article
- Article
- Effect of ultrasound-guided small needle knife on patients with knee osteoarthritis: a randomized clinical trial.Frontiers in medicine · 2026Article
- Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators.World journal of orthopedics · 2025Review
- Body roundness index and the risk of knee osteoarthritis: evidence from the China Health and Retirement Longitudinal Study.Frontiers in nutrition · 2025Article
- Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis.Journal of inflammation research · 2025Review
- Bottlebrush Polymers for Articular Joint Lubrication: Influence of Anchoring Group Chemistry on Lubrication Properties.ACS applied materials & interfaces · 2024Article
- Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study.BMC public health · 2024Article
- Multimorbidity patterns and the association with health status of the oldest-old in long-term care facilities in China: a two-step analysis.BMC geriatrics · 2023Article
- Effect of moderate exercise on osteoarthritis.EFORT open reviews · 2023Review
- CircRNAs in osteoarthritis: research status and prospect.Frontiers in genetics · 2023Review
- Metformin Reduces the Risk of Total Hip Arthroplasty in Elderly Patients with Hip Osteoarthritis and Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Diabetes-associated thigh muscle degeneration mediates knee osteoarthritis-related outcomes: results from a longitudinal cohort study.European radiology · 2023Article
- Metformin use and associated risk of total joint replacement in patients with type 2 diabetes: a population-based matched cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Statin use and MRI subchondral bone marrow lesion worsening in generalized osteoarthritis: longitudinal analysis from Osteoarthritis Initiative data.European radiology · 2022Article
- The association between preexisting conditions and osteoarthritis development in peripheral joints: A population based nested case-control study.Osteoarthritis and cartilage open · 2022Article
- Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.Biomedicines · 2022Review
- Synovial inflammation in osteoarthritis progression.Nature reviews. Rheumatology · 2022Review
- Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies.Current rheumatology reports · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThere is an interest in identifying a metabolic OA phenotype. We therefore assessed the relation of diabetes and cardiovascular disease to prevalent and incident radiographic (ROA) and symptomatic knee osteoarthritis (SxOA).
designIn two large cohort studies of individuals with or at risk for knee OA, the Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), participants self-reported diabetes and cardiovascular disease (CVD) at baseline. We assessed the relation of baseline diabetes and CVD (exposures) to ROA and SxOA cross-sectionally and after 60 (MOST) or 48 (OAI) months of follow-up using logistic regression with GEE to account for 2 knees within an individual, adjusting for potential confounders.
resultsIn MOST, 6,020 knees of 3,021 participants (60.1% female, mean ± SD age 62.5 ± 8.1, mean BMI 30.7 ± 6.0, 83.3% Caucasian) were included in the analyses. In OAI, 8,645 knees of 4,339 participants (58.2% female, mean ± SD age 61.1 ± 9.2, mean BMI 28.6 ± 4.8, 80.3% Caucasian) were included. We found no significant associations between prevalent diabetes or CVD and prevalent or incident ROA or SxOA. Effect estimates for prevalent ROA and SxOA ranged from 0.80 (95% CI 0.63-1.03) to 1.17 (0.91-1.51). Effect estimates for incident ROA ranged from 0.80 (0.58-1.11) to 0.88 (0.60-1.29) in MOST and from 0.75 (0.50-1.14) to 1.19 (0.81-1.74) in OAI, and for incident SxOA from 0.93 (0.65-1.31) to 1.22 (0.89-1.67) in MOST and from 0.82 (0.59-1.16) to 1.19 (0.85-1.66) in OAI).
conclusionsDiabetes and CVD were not associated with prevalent or incident knee OA.
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