Evidence map›Paper›PMID 33253594›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Role of Dual Oxidases in Ventilator-induced Lung Injury.

Laura Cagle, Angela Linderholm, Lisa Franzi, Sabrina Hoehne, Jerold Last, Nicholas Kenyon, Beate Illek, Richart Harper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of Dual Oxidases in Ventilator-induced Lung Injury.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura CagleUniversity of California Lung Center, University of California, Davis, Davis, California.ORCID 0000-0001-9926-7183
Angela LinderholmUniversity of California Lung Center, University of California, Davis, Davis, California.
Lisa FranziUniversity of California Lung Center, University of California, Davis, Davis, California.ORCID 0000-0003-4181-277X
Sabrina HoehneUniversity of California Lung Center, University of California, Davis, Davis, California.ORCID 0000-0002-0884-6268
Jerold LastUniversity of California Lung Center, University of California, Davis, Davis, California.
Nicholas KenyonUniversity of California Lung Center, University of California, Davis, Davis, California.ORCID 0000-0001-8839-4400
Beate IllekUCSF Benioff Children's Hospital, Children's Hospital Oakland Research Institute, Oakland, California.
Richart HarperUniversity of California Lung Center, University of California, Davis, Davis, California.ORCID 0000-0001-8097-6465
University of California, Davis · USVA Northern California Health Care System · USUCSF Benioff Children's Hospital · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and AdolescenceUH3OD023365 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Deborah Hall Bennett, Irva Hertz-Picciotto · 2018 to 2026
$21.9M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
Comparative Medical Science Training ProgramT32OD011147 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ, Sara Michelle Thomasy · 2012 to 2026
$5.5M
NHLBI NIH HHS T32 HL007013NIEHS NIH HHS P30 ES023513NIH HHS T32 OD011147NIH HHS UH3 OD023365
6 · The paper itself

Abstract

Positive-pressure ventilation results in ventilator-induced lung injury, and few therapeutic modalities have been successful at limiting the degree of injury to the lungs. Understanding the primary drivers of ventilator-induced lung injury will aid in the development of specific treatments to ameliorate the progression of this syndrome. There are conflicting data for the role of neutrophils in acute respiratory distress syndrome pathogenesis. Here, we specifically examined the importance of neutrophils as a primary driver of ventilator-induced lung injury in a mouse model known to have impaired ability to recruit neutrophils in previous models of inflammation. We exposed

Indexed as

AnimalsDual OxidasesHypoxiaLungMiceNeutrophilsOxygenPositive-Pressure RespirationRespirationRespiratory Distress SyndromeTidal VolumeVentilator-Induced Lung InjuryDual OxidasesOxygenacute lung injurydual oxidasesNADPH oxidasespositive-pressure ventilation

Identifiers

PMID33253594
PMCPMC7874397
OpenAlexW3107627816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.