Evidence map›Paper›PMID 33253592›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.

Al-Faraaz Kassam, Nick C Levinsky, Jaya P Mallela, Kira Angel, Amy Opoka, Patrick Lahni, Rashmi D Sahay, Lin Fei, Vanessa Nomellini, Hector R Wong and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Olfactomedin-4 elevation in pediatric acute respiratory distress syndrome.American journal of physiology. Lung cellular and molecular physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Al-Faraaz KassamDepartment of Surgery and.
Nick C LevinskyDepartment of Surgery and.
Jaya P MallelaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Kira AngelDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Amy OpokaDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Patrick LahniDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Rashmi D SahayDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Lin FeiDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.
Vanessa NomelliniDepartment of Surgery and.
Hector R WongDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.ORCID 0000-0001-7989-1173
Matthew N AlderDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio; and.ORCID 0000-0003-2879-6576
University of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · US

Funding

HOST RESPONSE TO TRAUMA RESEARCH TRAINING PROGRAMT32GM008478 · NIGMS · UNIVERSITY OF CINCINNATI · PI TIMOTHY A PRITTS, BASILIA ZINGARELLI · 1993 to 2026
$6.7M
Supplement for MIRA award_Wong_2021R35GM126943 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ALDER, MATTHEW N · 2018 to 2022
$2.7M
The Role of Olfactomedin 4 in Septic ShockK08GM124298 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ALDER, MATTHEW N · 2017 to 2020
$758k
NIGMS NIH HHS K08 GM124298NIGMS NIH HHS R35 GM126943NIGMS NIH HHS T32 GM008478
6 · The paper itself

Abstract

Neutrophils are vital to both the inflammatory cascade and tissue repair after an injury. Neutrophil heterogeneity is well established but there is less evidence for significant, different functional roles for neutrophil subsets. OLFM4 (Olfactomedin-4) is expressed by a subset of neutrophils, and high expression of

Indexed as

AdultAnimalsCytokinesDisease Models, AnimalFemaleGranulocyte Colony-Stimulating FactorHumansInflammationLungMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedNeutrophilsPeroxidaseCytokinesGranulocyte Colony-Stimulating FactorOLFM4 protein, humanPeroxidaseblunt traumatic injuryhemorrhagic shockneutrophilsOlfactomedin 4trauma

Identifiers

PMID33253592
PMCPMC7874390
OpenAlexW3107844071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.