Evidence map›Paper›PMID 33253414›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2021

Patterns of Load-to-Strength Ratios Along the Spine in a Population-Based Cohort to Evaluate the Contribution of Spinal Loading to Vertebral Fractures.

Hossein Mokhtarzadeh, Dennis E Anderson, Brett T Allaire, Mary L Bouxsein

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Hossein Mokhtarzadeh *Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-6519-7735
Dennis E AndersonCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-5171-7445
Brett T AllaireCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Mary L BouxseinCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-7027-7414
Beth Israel Deaconess Medical Center · USThe University of Melbourne · AU

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
Influence of Spinal Loading on Vertebral FractureR01AR073019 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUXSEIN, MARY L, SNYDER, BRIAN D · 2018 to 2022
$2.8M
Age-related Changes in Thoracic Spine BiomechanicsR00AG042458 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERSON, DENNIS · 2015 to 2017
$735k
NHLBI NIH HHS 75N92019D00031NIAMS NIH HHS R01 AR073019NIA NIH HHS R00 AG042458
6 · The paper itself

Abstract

Vertebral fractures (VFx) are common among older adults. Epidemiological studies report high occurrence of VFx at mid-thoracic and thoracolumbar regions of the spine; however, reasons for this observation remain poorly understood. Prior reports of high ratios of spinal loading to vertebral strength in the thoracolumbar region suggest a possible biomechanical explanation. However, no studies have evaluated load-to-strength ratios (LSRs) throughout the spine for a large number of activities in a sizeable cohort. Thus, we performed a cross-sectional study in a sample of adult men and women from a population-based cohort to: 1) determine which activities cause the largest vertebral LSRs, and 2) examine patterns of LSRs along the spine for these high-load activities. We used subject-specific musculoskeletal models of the trunk to determine vertebral compressive loads for 109 activities in 250 individuals (aged 41 to 90 years, 50% women) from the Framingham Heart Study. Vertebral compressive strengths from T

Indexed as

Spinal FracturesSpineAgedBone DensityCompressive StrengthCross-Sectional StudiesFemaleHumansLumbar VertebraeMaleBIOMECHANICSBONE QCTFRACTURE PREVENTIONFRACTURE RISK ASSESSMENTOSTEOPOROSIS

Identifiers

PMID33253414
PMCPMC8383210
OpenAlexW3109357357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.