ArticlePloS one2020
Rat donor lung quality deteriorates more after fast than slow brain death induction.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Evaluation of donor's hormonal profile according to sex and age.Frontiers in physiology · 2025Article
- Sex differences in kidney and lung status in an animal model of brain death.Clinics (Sao Paulo, Brazil) · 2025Article
- Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Angiotensin-converting enzyme 2 activation attenuates inflammation and oxidative stress in brain death donor followed by rat lung transplantation.Scientific reports · 2024Article
- Intestinal microbiota dysbiosis and liver metabolomic changes during brain death.Journal of intensive medicine · 2023Article
- Histological, Laboratorial, and Clinical Benefits of an Optimized Maintenance Strategy of a Potential Organ Donor-A Rabbit Experimental Model.Life (Basel, Switzerland) · 2023Article
- MG132 protects against lung injury following brain death in rats.Experimental and therapeutic medicine · 2022Article
- A translational rat model for ex vivo lung perfusion of pre-injured lungs after brain death.PloS one · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Donor brain death (BD) is initiated by an increase in intracranial pressure (ICP), which subsequently damages the donor lung. In this study, we investigated whether the speed of ICP increase affects quality of donor lungs, in a rat model for fast versus slow BD induction. Rats were assigned to 3 groups: 1) control, 2) fast BD induction (ICP increase over 1 min) or 3) slow BD induction (ICP increase over 30 min). BD was induced by epidural inflation of a balloon catheter. Brain-dead rats were sacrificed after 0.5 hours, 1 hour, 2 hours and 4 hours to study time-dependent changes. Hemodynamic stability, histological lung injury and inflammatory status were investigated. We found that fast BD induction compromised hemodynamic stability of rats more than slow BD induction, reflected by higher mean arterial pressures during the BD induction period and an increased need for hemodynamic support during the BD stabilization phase. Furthermore, fast BD induction increased histological lung injury scores and gene expression levels of TNF-α and MCP-1 at 0.5 hours after induction. Yet after donor stabilization, inflammatory status was comparable between the two BD models. This study demonstrates fast BD induction deteriorates quality of donor lungs more on a histological level than slow BD induction.
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