Evidence map›Paper›PMID 33253242›Full record

ArticlePLoS neglected tropical diseases2020

Early impairment of myocardial deformation assessed by regional speckle-tracking echocardiography in the indeterminate form of Chagas disease without fibrosis detected by cardiac magnetic resonance.

Minna Moreira Dias Romano, Henrique Turin Moreira, José Antônio Marin-Neto, Priscila Elias Baccelli, Fawaz Alenezi, Igor Klem, Benedito Carlos Maciel, Joseph Kisslo, André Schmidt, Eric J Velazquez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Minna Moreira Dias RomanoCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0002-8742-3764
Henrique Turin MoreiraCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0002-4543-4684
José Antônio Marin-NetoCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0002-8651-8833
Priscila Elias BaccelliCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0003-1971-468X
Fawaz AleneziCardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America.
Igor KlemCardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America.
Benedito Carlos MacielCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0002-3456-8433
Joseph KissloCardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America.
André SchmidtCardiology Center of the Medical School of Ribeirão Preto, Internal Medicine Department, University of São Paulo (USP), Brazil.ORCID 0000-0002-1090-8165
Eric J VelazquezCardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States of America.ORCID 0000-0003-2245-7477
Universidade de São Paulo · BRDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease (CD) will account for 200,000 cardiovascular deaths worldwide over the next 5 years. Early detection of chronic Chagas cardiomyopathy (CCC) is a challenge. We aimed to test if speckle-tracking echocardiography (STE) can detect incipient myocardial damage in CD.

methodsAmong 325 individuals with positive serological tests, 25 (age 55±12yrs) were selected to compose the group with indeterminate form of Chagas disease (IFCD), based on stringent criteria of being asymptomatic and with normal EKG/X-ray studies. This group was compared with a group of 20 patients with CCC (55±11yrs) and a group of 20 non-infected matched control (NC) subjects (48±10yrs). CD patients and NC were submitted to STE and CD patients were submitted to cardiac magnetic resonance (CMR) with late gadolinium administration to detect cardiac fibrosis by the late enhancement technique. Global longitudinal strain (GLS), circumferential (GCS) and radial strain (GRS) were defined as the average of segments measured from three apical view (GLS) and short axis views (GRS and GCS). Regional left ventricular (LV) longitudinal strain (Reg LS) was measured from each of the 17 segments. Twist was measured as systolic peak difference between basal and apical rotation and indexed to LV length to express torsion.

resultsSTE global indices (GLS, GCS, twist and torsion) were reduced in CCC vs NC (GLS: -14±6.3% vs -19.3±1.6%, p = 0.001; GCS: -13.6±5.2% vs -17.3 ±2.8%; p = 0.008; twist: 8±7° vs 14±7°, p = 0.01 and torsion: 0.96±1°/cm vs 1.9±1°/cm, p = 0.005), but showed no differences in IFCD vs NC. RegLS was reduced in IFCD vs NC in four LV segments: basal-inferior (-16.3±3.3% vs -18.6±2.2%, p = 0.013), basal inferoseptal (-13.1±3.4 vs -15.2±2.7, p = 0.019), mid-inferoseptal (-17.7±3.2 vs -19.4±2, p = 0.032) and mid-inferolateral (-15.2±3.5 vs -17.8±2.8, p = 0.014). These abnormalities in RegLS occurred in the absence of myocardial fibrosis detectable with CMR in nearly 92% of subjects with IFCD, while myocardial fibrosis was present in 65% with CCC.

conclusionRegLS detects early regional impairment of myocardial strain that is independent from fibrosis in IFCD subjects.

Indexed as

AdultCase-Control StudiesChagas CardiomyopathyEchocardiographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumTrypanosoma cruziVentricular Dysfunction, Left

Identifiers

PMID33253242
PMCPMC7728209
OpenAlexW3108133582

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.