ArticlePLoS neglected tropical diseases2020
Transmission competence of a new mesonivirus, Yichang virus, in mosquitoes and its interference with representative flaviviruses.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of insect-specific viruses on transmission, infection, and replication of arboviruses in co-infected mosquitoes: a systematic review.Parasites & vectors · 2026Pooled it
- First molecular detection of the genus Almendravirus in Johnbelkinia ulopus and Anopheles apicimacula mosquitoes from the Colombian Caribbean.Parasites & vectors · 2026Article
- Insect-specific Alphamesonivirus-1 (Journal of virology · 2025Article
- Article
- Article
- Cell fusing agent virus rarely transmits vertically in artificially infected laboratory-colonized Aedes aegypti mosquitoes.Parasites & vectors · 2024Article
- Interaction of Mesonivirus and Negevirus with arboviruses and the RNAi response in Culex tarsalis-derived cells.Parasites & vectors · 2023Article
- TargetingViruses · 2023Review
- Spatial scale influences the distribution of viral diversity in the eukaryotic virome of the mosquitoVirus evolution · 2023Article
- Clinical features and transmission risk analysis of dengue virus infections in Shenzhen, During 2014-2019.Computational and structural biotechnology journal · 2023Article
- Negeviruses Reduce Replication of Alphaviruses during Coinfection.Journal of virology · 2021Article
- Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in technology have greatly stimulated the understanding of insect-specific viruses (ISVs). Unfortunately, most of these findings are based on sequencing technology, and laboratory data are scarce on the transmission dynamics of ISVs in nature and the potential effects of these viruses on arboviruses. Mesonivirus is a class of ISVs with a wide geographical distribution. Recently, our laboratory reported the isolation of a novel strain of mesonivirus, Yichang virus (YCV), from Culex mosquitoes, China. In this study, the experimental infection of YCV by the oral route for adult and larvae mosquitoes, and the vertical transmission has been conducted, which suggests that YCV could adopt a mixed-mode transmission. Controlled experiments showed that the infectivity of YCV depends on the mosquito species, virus dose, and infection route. The proliferation curve and tissue distribution of YCV in Cx. quinquefasciatus and Ae. albopictus showed that YCV is more susceptible to Ae. albopictus and is located in the midgut. Furthermore, we also assessed the interference of YCV with flaviviruses both in vitro and in vivo. YCV significantly inhibited the proliferation of DENV-2 and ZIKV, in cell culture, and reduced transmission rate of DENV-2 in Ae. albopictus. Our work provides insights into the transmission of ISVs in different mosquito species during ontogeny and their potential ability to interact with mosquito-borne viruses.
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