ArticlePLoS biology2020
A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Top-down feedback in deep neural networks leads to functional differences during audiovisual integration.eLife · 2026Article
- Multiscale structural connectome eigenmodes constrain human brain functional dynamics.Communications biology · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Human cortical dynamics reflect graded contributions of local geometry and network topography.Nature communications · 2025Article
- Evidence for divergent cortical organisation in Parkinson's disease and Lewy Body Dementia.Nature communications · 2025Article
- The effective connectome over a century of human life.Communications biology · 2025Article
- Brain Myelin Covariance Networks: Gradients, Cognition, and Higher-Order Landscape.Behavioral sciences (Basel, Switzerland) · 2025Article
- HippoMaps: multiscale cartography of human hippocampal organization.Nature methods · 2025Article
- Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies.Communications biology · 2025Article
- The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization.PLoS biology · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantifying the influence of biophysical factors in shaping brain communication through remnant functional networks.Network neuroscience (Cambridge, Mass.) · 2025Article
- The cell-type underpinnings of the human functional cortical connectome.Nature neuroscience · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- Article
- Explaining slow seizure propagation with white matter tractography.Brain : a journal of neurology · 2024Article
- Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.Neuroinformatics · 2024Review
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Authors and funding
13 authors.
Funding
Abstract
The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model of its connectivity. Our approach is inspired by seminal, but so far largely neglected models of cortico-cortical wiring established by postmortem anatomical studies and capitalises on cutting-edge in vivo neuroimaging and machine learning. The new model expands the currently prevailing diffusion magnetic resonance imaging (MRI) tractography approach by incorporation of additional features of cortical microstructure and cortico-cortical proximity. Studying several datasets and different parcellation schemes, we could show that our coordinate system robustly recapitulates established sensory-limbic and anterior-posterior dimensions of brain organisation. A series of validation experiments showed that the new wiring space reflects cortical microcircuit features (including pyramidal neuron depth and glial expression) and allowed for competitive simulations of functional connectivity and dynamics based on resting-state functional magnetic resonance imaging (rs-fMRI) and human intracranial electroencephalography (EEG) coherence. Our results advance our understanding of how cell-specific neurobiological gradients produce a hierarchical cortical wiring scheme that is concordant with increasing functional sophistication of human brain organisation. Our evaluations demonstrate the cortical wiring space bridges across scales of neural organisation and can be easily translated to single individuals.
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