ArticlePloS one2020
Genetic and reproductive consequences of consanguineous marriage in Bangladesh.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Thalassemia and hemoglobinopathy prevalence in a community-based sample in Sylhet, Bangladesh.Orphanet journal of rare diseases · 2023Trial
- Negotiating genetic risk in Indonesia: Development and psychometric evaluation of the knowledge and attitude toward consanguineous marriage instrument in a mixed-methods cross-sectional study.Journal of community genetics · 2026Article
- Article
- Familial, environmental, and pregnancy-related risk factors for anorectal malformations in Pakistani newborns: a hospital-based case-control study.BMC pediatrics · 2026Article
- Article
- Impact of consanguineous marriage on developmental dental anomalies: a cross-sectional study.BMC oral health · 2026Article
- Genealogical Identification and Short Tandem Repeat-Based Verification of Suspected Consanguinity in Mongolian Families.The application of clinical genetics · 2026Article
- A Novel Deep-IntronicThe application of clinical genetics · 2026Article
- Clinical, Hematological, and Nutritional Profiling of Thalassemia Patients: Insights From a Cross-Sectional Study.Anemia · 2026Article
- Consanguinity and willingness to perform premarital genetic screening in Sudan.European journal of human genetics : EJHG · 2025Article
- Inbreeding and deleterious variation in South Asian populations.Scientific reports · 2025Article
- Incidence of neural tube defects in tertiary care university hospital in Bangladesh.Clinical and experimental pediatrics · 2025Article
- Influence of Consanguinity on Non-communicable Diseases in Settat, Morocco: Exploring Susceptibility to Chronic and Complex Health Conditions.Journal of research in health sciences · 2025Article
- Emphasizing the need for preconceptional, prenatal genetic counseling and comprehensive genetic testing in consanguinity: challenges and experience.Molecular genetics and genomics : MGG · 2024Article
- Griscelli syndrome: a diagnostic challenge of a rare disease: a case report.Annals of medicine and surgery (2012) · 2024Article
- Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate.European journal of dentistry · 2024Article
- Evolution of orthopaedic diseases through four thousand three hundred years: from ancient Egypt with virtual examinations of mummies to the twenty-first century.International orthopaedics · 2024Article
- Title-molecular diagnostics of dystrophinopathies in Sri Lanka towards phenotype predictions: an insight from a South Asian resource limited setting.European journal of medical research · 2024Article
- Assessing Students' Knowledge and Attitudes Regarding the Risks and Prevention of Consanguineous Marriage: A Cross-Sectional Online Survey.Journal of multidisciplinary healthcare · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to assess the prevalence, sociodemographic factors, reproductive consequences, and heritable disease burdens associated with consanguineous marriage (CM) in Bangladesh.
methodsA total of 7,312 families, including 3,694 CM-families, were recruited from 102 locales of 58 districts of Bangladesh. Using a standard questionnaire, we collected medical history and background sociodemographic data of these families. Family history was assessed by pedigree analysis. Fertility, mortality, secondary sex ratio, selection intensity, lethal equivalents were measured using standard methods.
resultsThe mean prevalence of CM in our studied population was 6.64%. Gross fertility was higher among CM families, as compared to the non-CM families (p < 0.05). The rate of under-5 child (U5) mortality was significantly higher among CM families (16.6%) in comparison with the non-CM families (5.8%) (p < 0.01). We observed a persuasive rise of abortion/miscarriage and U5 mortality rates with the increasing level of inbreeding. The value of lethal equivalents per gamete found elevated for autosomal inheritances as compared to sex-linked inheritance. CM was associated with the incidence of several single-gene and multifactorial diseases, and congenital malformations, including bronchial asthma, hearing defect, heart diseases, sickle cell anemia (p < 0.05). The general attitude and perception toward CM were rather indifferent, and very few people were concerned about its genetic burden.
conclusionThis study highlights the harmful consequences of CM on reproductive behavior and the incidence of hereditary conditions. It essences the need for genetic counseling from premarital to postnatal levels in Bangladesh.
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