ArticlePLoS biology2020
Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Reorganization of E-cadherin into apical spot junctions mediates interlineage adhesion between epithelial and germline cells.Frontiers in cell and developmental biology · 2026Article
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- Surface mechanics and compressive stress impact mammalian follicle development.Nature communications · 2025Article
- Mechanical contribution of germ cell specification inScience advances · 2025Article
- Inferring diffusion, reaction, and exchange parameters from imperfect FRAP.Biophysical journal · 2025Article
- In situ quantification of osmotic pressure within living embryonic tissues.Nature communications · 2023Article
- The mechanics of cephalic furrow formation in the Drosophila embryo.Biophysical journal · 2023Article
- Constriction imposed by basement membrane regulates developmental cell migration.PLoS biology · 2023Article
- Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.Nature communications · 2022Article
- A hydro-osmotic coarsening theory of biological cavity formation.PLoS computational biology · 2021Article
- Dynamics of hydraulic and contractile wave-mediated fluid transport duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is unknown how growth in one tissue impacts morphogenesis in a neighboring tissue. To address this, we used the Drosophila ovarian follicle, in which a cluster of 15 nurse cells and a posteriorly located oocyte are surrounded by a layer of epithelial cells. It is known that as the nurse cells grow, the overlying epithelial cells flatten in a wave that begins in the anterior. Here, we demonstrate that an anterior to posterior gradient of decreasing cytoplasmic pressure is present across the nurse cells and that this gradient acts through TGFβ to control both the triggering and the progression of the wave of epithelial cell flattening. Our data indicate that intrinsic nurse cell growth is important to control proper nurse cell pressure. Finally, we reveal that nurse cell pressure and subsequent TGFβ activity in the stretched cells combine to increase follicle elongation in the anterior, which is crucial for allowing nurse cell growth and pressure control. More generally, our results reveal that during development, inner cytoplasmic pressure in individual cells has an important role in shaping their neighbors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.