Evidence map›Paper›PMID 33253160›Full record

ArticlePLoS computational biology2020

Inferring a network from dynamical signals at its nodes.

Corey Weistuch, Luca Agozzino, Lilianne R Mujica-Parodi, Ken A Dill

Abstract read
In one paragraph

Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Corey WeistuchLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-6044-2511
Luca AgozzinoLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-6760-4402
Lilianne R Mujica-ParodiLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0002-3752-5519
Ken A DillLaufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We give an approximate solution to the difficult inverse problem of inferring the topology of an unknown network from given time-dependent signals at the nodes. For example, we measure signals from individual neurons in the brain, and infer how they are inter-connected. We use Maximum Caliber as an inference principle. The combinatorial challenge of high-dimensional data is handled using two different approximations to the pairwise couplings. We show two proofs of principle: in a nonlinear genetic toggle switch circuit, and in a toy neural network.

Indexed as

Neural Networks, ComputerAction PotentialsAlgorithmsBrainGene Regulatory NetworksNeuronsProof of Concept Study

Identifiers

PMID33253160
PMCPMC7728228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.