Evidence map›Paper›PMID 33252985›Full record

Trial reportAmerican journal of respiratory and critical care medicine2021

Reduced All-Cause Mortality in the ETHOS Trial of Budesonide/Glycopyrrolate/Formoterol for Chronic Obstructive Pulmonary Disease. A Randomized, Double-Blind, Multicenter, Parallel-Group Study.

Fernando J Martinez, Klaus F Rabe, Gary T Ferguson, Jadwiga A Wedzicha, Dave Singh, Chen Wang, Kimberly Rossman, Earl St Rose, Roopa Trivedi, Shaila Ballal and 4 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 10 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 10 syntheses or guidelines pooled it, 250 citations in OpenAlex.

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  5. Digital remote maintenance inhaler adherence interventions in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Fernando J MartinezJoan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York.
Klaus F RabeLungenClinic Grosshansdorf and Christian-Albrechts University Kiel, Airway Research Center North, Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.
Gary T FergusonPulmonary Research Institute of Southeast Michigan, Farmington Hills, Michigan.
Jadwiga A WedzichaNational Heart and Lung Institute, London, United Kingdom.
Dave SinghMedicines Evaluation Unit, University of Manchester, Manchester University NHS Foundation Hospitals Trust, Manchester, United Kingdom.
Chen WangNational Clinical Research Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
Kimberly RossmanAstraZeneca, Morristown, New Jersey.
Earl St RoseAstraZeneca, Morristown, New Jersey.
Roopa TrivediAstraZeneca, Durham, North Carolina.
Shaila BallalAstraZeneca, Morristown, New Jersey.
Patrick DarkenAstraZeneca, Wilmington, Delaware; and.
Magnus AurivilliusAstraZeneca, Gothenburg, Sweden.
Colin ReisnerAstraZeneca, Morristown, New Jersey.
Paul DorinskyAstraZeneca, Durham, North Carolina.
AstraZeneca (United States) · USAstraZeneca (Sweden) · SEBritish Lung Foundation · GBChina-Japan Friendship Hospital · CNCornell University · USGerman Center for Lung Research · DEUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MortalityAgedBronchodilator AgentsBudesonideCause of DeathDouble-Blind MethodDrug Therapy, CombinationFemaleForced Expiratory VolumeFormoterol FumarateGlucocorticoidsGlycopyrrolateHumansKaplan-Meier EstimateMaleMiddle AgedBronchodilator AgentsBudesonideFormoterol FumarateGlucocorticoidsGlycopyrrolateMuscarinic AntagonistsBGF metered-dose inhalerchronic obstructive pulmonary diseaseinhaled corticosteroids/long-acting muscarinic antagonist/long-acting β2-agonistmortalitytriple therapy

Identifiers

PMID33252985
PMCPMC7924571
OpenAlexW3108245859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.