Evidence map›Paper›PMID 33252847›Full record

ArticleCurrent protocols in immunology2020

Protocols for Experimental Sjögren's Syndrome.

Harini Bagavant, Umesh S Deshmukh

Open access · greenAbstract read
In one paragraph

Article in Current protocols in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Dysregulated CaeLife · 2024
    Article
  5. Dysregulated CabioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Harini BagavantArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Umesh S DeshmukhArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Oklahoma Medical Research Foundation · US

Funding

Innate immunity and autoantibodies in the pathogenesis of Sjogren's SyndromeR01DE025030 · NIDCR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI DESHMUKH, UMESH S · 2016 to 2020
$2.2M
Cytosolic DNA sensing pathway in the pathogenesis of Sjogren's SyndromeR21DE029707 · NIDCR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI DESHMUKH, UMESH S · 2020 to 2021
$481k
NIDCR NIH HHS R01 DE025030NIDCR NIH HHS R21 DE029707
6 · The paper itself

Abstract

Sjögren's syndrome (SS) is a systemic autoimmune disease affecting multiple organ systems. Salivary and lacrimal gland involvement cause dry mouth and dry eye and are the most common clinical presentations of the disease. Patients with SS also have autoantibodies targeting multiple nuclear and cytoplasmic antigens. Innate immune activation plays a critical role in SS pathogenesis. This article describes the activation of specific innate immune pathways in mice to study SS salivary gland manifestations. Methodologies for evaluating salivary gland inflammation and salivary function are described. This article also describes protocols for in-house assays to measure autoantibody titers in serum. © 2020 Wiley Periodicals LLC Basic Protocol 1: Acceleration of Sjögren's syndrome by activating the toll-like receptor 3 pathway Basic Protocol 2: Induction of Sjögren's syndrome by activating the stimulator of interferon genes pathway Alternate Protocol: Acceleration of Sjögren's syndrome by the administration of Freund's incomplete adjuvant Support Protocol 1: Evaluating salivary gland function Support Protocol 2: Evaluating salivary gland inflammation Support Protocol 3: Measuring autoantibody titers by indirect immunofluorescence.

Indexed as

AnimalsCell Culture TechniquesHumansImmunity, InnateInflammationInterferonsMiceModels, AnimalSalivary GlandsSjogren's SyndromeInterferonsinnate immunitysalivary glandsSjögren's syndromeSTINGTLR3

Identifiers

PMID33252847
PMCPMC8959043
OpenAlexW3107654540

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.