ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Relationships Between Sensorimotor Inhibition and Mobility in Older Adults With and Without Parkinson's Disease.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720810 (Pacific Northwest Udall Center), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pacific Northwest Udall Center (PANUC) Clinical Core
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Neuroimaging and cognitive correlates of postural control in Parkinson's disease: a systematic review.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Short-Latency Afferent Inhibition and Cognitive Function in Older Adults With Mild Cognitive Impairment: A Pilot Study.Brain & NeuroRehabilitation · 2026Article
- Machine Learning Predicts Risk of Falls in Parkison's Disease Patients in a Multicenter Observational Study.European journal of neurology · 2025Observational
- Occurrence of Motor Complications and Gait Problems After Introduction of Medical Treatment in Parkinson's Disease.Parkinson's disease · 2025Article
- Prevention of Falls in Parkinson's Disease: Guidelines and Gaps.Movement disorders clinical practice · 2023Review
- Exploring the effects of dopamine on sensorimotor inhibition and mobility in older adults.Experimental brain research · 2023Article
- An investigation of the contribution of different turn speeds during standing turns in individuals with and without Parkinson's disease.Scientific reports · 2022Article
- Feasibility of a Novel Therapist-Assisted Feedback System for Gait Training in Parkinson's Disease.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundReduced cortical sensorimotor inhibition is associated with mobility and cognitive impairments in people with Parkinson's disease (PD) and older adults (OAs). However, there is a lack of clarity regarding the relationships among sensorimotor, cognitive, and mobility impairments. The purpose of this study was to determine how cortical sensorimotor inhibition relates to impairments in mobility and cognition in people with PD and OAs.
methodCortical sensorimotor inhibition was characterized with short-latency afferent inhibition (SAI) in 81 people with PD and 69 OAs. Six inertial sensors recorded single- and dual-task gait and postural sway characteristics during a 2-minute walk and a 1-minute quiet stance. Cognition was assessed across the memory, visuospatial, executive function, attention, and language domains.
resultsSAI was significantly impaired in the PD compared to the OA group. The PD group preformed significantly worse across all gait and postural sway tasks. In PD, SAI significantly correlated with single-task foot strike angle and stride length variability, sway area, and jerkiness of sway in the coronal and sagittal planes. In OAs, SAI significantly related to single-task gait speed and stride length, dual-task stride length, and immediate recall (memory domain). No relationship among mobility, cognition, and SAI was observed.
conclusionsImpaired SAI related to slower gait in OA and to increased gait variability and postural sway in people with PD, all of which have been shown to be related to increased fall risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.