ArticleJournal of Alzheimer's disease : JAD2020
Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer's Disease and Dementia: A Systematic Review.Nutrients · 2025Pooled it
- Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization.The journal of prevention of Alzheimer's disease · 2026Observational
- The Relationship Between Dietary Sodium Intake and Cognitive Function: A Narrative Review.Current nutrition reports · 2026Review
- Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity.medRxiv : the preprint server for health sciences · 2025Article
- Risk factors and predictive model for mild cognitive impairment in elderly patients with rheumatoid arthritis.BMC rheumatology · 2025Article
- Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.Food science & nutrition · 2025Article
- Social Activities and Cognitive Functioning Across Mid- and Late Life: Evidence From China.The Gerontologist · 2025Article
- The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review.Nutrients · 2024Review
- Association between the Intake/Type of Cheese and Cognitive Function in Community-Dwelling Older Women in Japan: A Cross-Sectional Cohort Study.Nutrients · 2024Article
- Serum zinc concentration and dietary zinc intake in relation to cognitive function: an analysis of the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.European journal of nutrition · 2024Article
- Association between adding salt in food and dementia in European descent: A mendelian randomization study.Brain and behavior · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Effectiveness of dairy products to protect against cognitive decline in later life: a narrative review.Frontiers in nutrition · 2024Review
- An Interpretable Population Graph Network to Identify Rapid Progression of Alzheimer's Disease Using UK Biobank.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Article
- The role of plasma cortisol in dementia, epilepsy, and multiple sclerosis: A Mendelian randomization study.Frontiers in endocrinology · 2023Article
- A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases.Human genomics · 2022Review
- Beer, wine, and spirits differentially influence body composition in older white adults-a United Kingdom Biobank study.Obesity science & practice · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD (FH) or APOE4 (ɛ4).
objectiveObserve how the total diet is associated with long-term cognition among mid- to late-life populations at-risk and not-at-risk for AD.
methodsAmong 1,787 mid-to-late-aged adult UK Biobank participants, 10-year FI trajectories were modeled and regressed onto the total diet based on self-reported intake of 49 whole foods from a Food Frequency Questionnaire (FFQ).
resultsDaily cheese intake strongly predicted better FIT scores over time (FH-: β= 0.207, p < 0.001; ɛ4-: β= 0.073, p = 0.008; ɛ4+: β= 0.162, p = 0.001). Alcohol of any type daily also appeared beneficial (ɛ4+: β= 0.101, p = 0.022) and red wine was sometimes additionally protective (FH+: β= 0.100, p = 0.014; ɛ4-: β= 0.59, p = 0.039). Consuming lamb weekly was associated with improved outcomes (FH-: β= 0.066, p = 0.008; ɛ4+: β= 0.097, p = 0.044). Among at risk groups, added salt correlated with decreased performance (FH+: β= -0.114, p = 0.004; ɛ4+: β= -0.121, p = 0.009).
conclusionModifying meal plans may help minimize cognitive decline. We observed that added salt may put at-risk individuals at greater risk, but did not observe similar interactions among FH- and AD- individuals. Observations further suggest in risk status-dependent manners that adding cheese and red wine to the diet daily, and lamb on a weekly basis, may also improve long-term cognitive outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.