Evidence map›Paper›PMID 33252078›Full record

ArticleJournal of Alzheimer's disease : JAD2021

Plasma Biomarkers of Alzheimer's Disease in African Americans.

Kaancan Deniz, Charlotte C G Ho, Kimberly G Malphrus, Joseph S Reddy, Thuy Nguyen, Troy P Carnwath, Julia E Crook, John A Lucas, Neill R Graff-Radford, Minerva M Carrasquillo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Observational
  6. Review
  7. Novel set of plasma proteins classifies Alzheimer's dementia in African American individuals with high accuracy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Evaluation of plasma p-tau217 for detecting amyloid pathology in a heterogeneous community-based cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Associations of potential ADRD plasma biomarkers in cognitively normal volunteers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kaancan DenizMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Charlotte C G HoMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Kimberly G MalphrusMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Joseph S ReddyMayo Clinic, Department of Health Science Research, Jacksonville, FL, USA.
Thuy NguyenMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Troy P CarnwathMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Julia E CrookMayo Clinic, Department of Health Science Research, Jacksonville, FL, USA.
John A LucasMayo Clinic, Department of Psychiatry and Psychology, Jacksonville, FL, USA.
Neill R Graff-RadfordMayo Clinic, Department of Neurology, Jacksonville, FL, USA.
Minerva M CarrasquilloMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Nilüfer Ertekin-TanerMayo Clinic, Department of Neuroscience, Jacksonville, FL, USA.
Mayo Clinic in Florida · USWinnMed · USJacksonville College · US

Funding

Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Harnessing Molecular Networks of Resilience for Therapeutic Discoveries in ADR01AG061796 · NIA · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2018 to 2022
$5.7M
NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG061796NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG046139
6 · The paper itself

Abstract

BACKGROUND/

objectiveThe aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans.

methodsWe evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations.

resultsPlasma tau levels were higher in AD when adjusted for biological and technical covariates. APOEɛ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42.

conclusionWe identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.

Indexed as

Black or African AmericanAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesApolipoproteins ECase-Control StudiesFemaleHumansInterleukin-10Interleukin-6MaleMiddle AgedPeptide Fragmentstau ProteinsTumor Necrosis Factor-alphaAmyloid beta-Peptidesamyloid beta-protein (1-42)Apolipoproteins EIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6MAPT protein, humanPeptide Fragmentstau ProteinsTNF protein, humanTumor Necrosis Factor-alphaAfrican AmericansAlzheimer’s diseasebiomarkersminority health

Identifiers

PMID33252078
PMCPMC7902984
OpenAlexW3106852472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.