Evidence map›Paper›PMID 33251680›Full record

ArticlePain practice : the official journal of World Institute of Pain2021

Sex-specific Differences in Multisite Pain Presentation among Adults with Lower-Limb Loss.

Emma Haldane Beisheim, Mayank Seth, John Robert Horne, Gregory Evan Hicks, Ryan Todd Pohlig, Jaclyn Megan Sions

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain practice : the official journal of World Institute of Pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Mechanical Pain Sensitivity in Postamputation Pain.The Clinical journal of pain · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Emma Haldane BeisheimDepartment of Physical Therapy, University of Delaware, Newark, Delaware, U.S.A.
Mayank SethDepartment of Physical Therapy, University of Delaware, Newark, Delaware, U.S.A.
John Robert HorneIndependence Prosthetics-Orthotics, Inc., Newark, Delaware, U.S.A.
Gregory Evan HicksDepartment of Physical Therapy, University of Delaware, Newark, Delaware, U.S.A.
Ryan Todd PohligUniversity of Delaware Biostatistics Core Facility, Newark, Delaware, U.S.A.
Jaclyn Megan SionsDepartment of Physical Therapy, University of Delaware, Newark, Delaware, U.S.A.ORCID 0000-0002-8151-1341
University of Delaware · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
Trunk Muscle Characteristics and their Association with Balance, Function, and Participation among Individuals with AmputationsR03HD088668 · NICHD · UNIVERSITY OF DELAWARE · PI SIONS, JACLYN MEGAN · 2017 to 2018
$156k
NICHD NIH HHS R03 HD088668NICHD NIH HHS R03HD088668NICHD NIH HHS T32 HD007490NICHD NIH HHS T32HD007490NIGMS NIH HHS U54 GM104941NIGMS NIH HHS U54GM104941
6 · The paper itself

Abstract

objectivesMultisite pain remains significantly understudied following lower-limb loss (LLL), especially among females. This study aimed to explore sex-specific differences in the presentation of multisite pain post LLL. Hypotheses were multisite pain would be more prevalent among females post LLL as compared with males, and female sex would be significantly associated with multisite pain prevalence.

methodsIn this cross-sectional study, participants answered standardized questions regarding the presence of amputation-specific (ie, phantom-limb, residual-limb) and secondary (ie, contralateral-limb, low-back) pain. Multisite pain was defined as pain in ≥ 2 locations. Sex-specific differences in pain prevalence were evaluated using chi-square tests (P ≤ 0.050). Using logistic regression, the association between sex and multisite pain was examined after controlling for covariates (age, body mass index, time since amputation, amputation etiology and level).

resultsThe sample included 303 adults (33% females) ≥ 1 year post unilateral LLL. More females than males reported pain in the residual limb (53.0% vs. 38.4%), low back (56.0% vs. 39.9%), contralateral knee (37.0% vs. 24.1%), and contralateral hip (25.0% vs. 12.3%; P < 0.050). More females than males were classified as having multisite pain (72.0% vs. 54.7%; P = 0.004). While patterns of multisite pain were similar (ie, pain affected both amputation-specific and secondary sites) between sexes, being female was independently associated with higher odds of having multisite pain (odds ratio: 2.40, 95% confidence interval: 1.40 to 4.12). DISCUSSION: Female sex appears to be associated with multisite pain ≥ 1 year after LLL. Future work is needed to identify mechanisms underlying sex-specific differences in pain presentation and evaluate the impact of sex on pain-related outcomes post amputation.

Indexed as

AmputeesPain PerceptionPhantom LimbAdultAmputation, SurgicalCross-Sectional StudiesFemaleHumansLower ExtremityMaleSex Factorsamputationlow-back painlower-limb painpersistent painphantom-limb pain

Identifiers

PMID33251680
PMCPMC8035227
OpenAlexW3106926248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.