ArticleBioactive materials2021
Thermo-responsive imprinted hydrogel with switchable sialic acid recognition for selective cancer cell isolation from blood.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Application of Hydrogel in the Capture and Detection of Circulating Tumor Cells.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- [Design and synthesis of molecularly imprinted polymers and their applications in medical diagnosis and biocatalysis].Se pu = Chinese journal of chromatography · 2026Review
- [Research progress of molecular imprinting technology in the field of disease diagnosis and therapy].Se pu = Chinese journal of chromatography · 2026Review
- [Molecular imprinting strategies and advances targeting biomembranes].Se pu = Chinese journal of chromatography · 2026Review
- [Advances in application of cell imprinting technology in biomedical field].Se pu = Chinese journal of chromatography · 2026Review
- Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications.Bioactive materials · 2025Review
- Molecularly Imprinted Polymers Coupled with Cellulosic Paper-Based Analytical Devices for Biosensing Applications.Indian journal of microbiology · 2025Article
- Nano-crosslinked dynamic hydrogels for biomedical applications.Materials today. Bio · 2023Review
- Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications.Biomaterials research · 2023Review
- Regulated extravascular microenvironmentBioactive materials · 2023Article
- Determination of total cathinones with a single molecularly imprinted fluorescent sensor assisted by electromembrane microextraction.Mikrochimica acta · 2022Article
- Molecularly imprinted polymers for selective extraction/microextraction of cancer biomarkers: A review.Mikrochimica acta · 2022Review
- Reversible dougong structured receptor-ligand recognition for building dynamic extracellular matrix mimics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects.Exploration (Beijing, China) · 2022Review
- The promising use of nano-molecular imprinted templates for improved SARS-CoV-2 detection, drug delivery and research.Journal of nanobiotechnology · 2021Review
- Typical Fluorescent Sensors Exploiting Molecularly Imprinted Hydrogels for Environmentally and Medicinally Important Analytes Detection.Gels (Basel, Switzerland) · 2021Article
- Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, a sialic acid (SA)-imprinted thermo-responsive hydrogel layer was prepared for selective capture and release of cancer cells. The SA-imprinting process was performed at 37 °C using thermo-responsive functional monomer, thus generating switchable SA-recognition sites with potent SA binding at 37 °C and weak binding at a lower temperature (e.g., 25 °C). Since SA is often overexpressed at the glycan terminals of cell membrane proteins or lipids, the SA-imprinted hydrogel layer could be used for selective cancer cell recognition. Our results confirmed that the hydrogel layer could efficiently capture cancer cells from not only the culture medium but also the real blood samples. In addition, the captured cells could be non-invasively released by lowing the temperature. Considering the non-invasive processing mode, considerable capture efficiency, good cell selectivity, as well as the more stable and durable SA-imprinted sites compared to natural antibodies or receptors, this thermo-responsive hydrogel layer could be used as a promising and general platform for cell-based cancer diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.