Evidence map›Paper›PMID 33251374›Full record

ArticleAmerican journal of ophthalmology case reports2020

Unique and progressive retinal degeneration in a patient with cancer associated retinopathy.

Kei Mizobuchi, Satoshi Katagiri, Takaaki Hayashi, Wakana Ninomiya, Sachiyo Okude, Yasuhiko Asano, Makoto Zenno, Fumihito Hikage, Hiroshi Ohguro, Yasutsugu Ishiba and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Kei MizobuchiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Satoshi KatagiriDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Wakana NinomiyaDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Sachiyo OkudeDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Yasuhiko AsanoDepartment of Ophthalmology, Fujiyoshida Municipal Medical Center, Japan.
Makoto ZennoDepartment of Ophthalmology, Fujiyoshida Municipal Medical Center, Japan.
Fumihito HikageDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
Hiroshi OhguroDepartment of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
Yasutsugu IshibaDivision of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Sumiko WatanabeDivision of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Atsushi MizotaDepartment of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Jikei University School of Medicine · JPSapporo Medical University · JPShowa University · JPThe University of Tokyo · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report clinical course of a patient with cancer-associated retinopathy (CAR) medicated by steroid therapy, focusing on retinal degeneration progression. OBSERVATIONS: A 67 years-old female patient, who had a surgical history of endometrial carcinoma with adjuvant chemotherapy, was referred to our hospitals for the complaints of sudden reduced visual acuity and visual field constriction in the right eye. Best corrected visual acuity (BCVA) was 0.4 and 1.0 in right and left eyes, respectively. Funduscopy showed almost normal appearance in both eyes. Fluorescein angiography showed slight fluorescein leakage from the optic disc in both eyes and an inferior arcade vessel in the right eye. Optical coherence tomography (OCT) images showed loss of ellipsoid zone (EZ) and thinning of outer retinal layers at the nasal area of the fovea in both eyes. Goldmann perimetry (GP) demonstrated several paracentral absolute scotomas with peripheral visual field constriction in the right eye, and a paracentral relative scotoma with preserved peripheral visual field in the left eye. Ten months after the first visit, retinopathy progressed in both eyes. Funduscopy indicated mild retinal degeneration along with arcade veins with white sheathing of retinal arteries. Slightly visible EZ at the fovea and loss of EZ and interdigitation zone and thinning of outer retinal layers at other areas were observed in OCT images from both eyes. GP showed no response in both eyes. Oral prednisolone therapy was started and gradually tapered over a 3-month period. Twelve and fifteen months after the first visit, BCVA, EZ at the fovea in OCT images, and visual field gradually improved, whereas retinal degeneration along arcade veins became apparent. CONCLUSIONS AND IMPORTANCE: We reported a patient with CAR who exhibited progressive retinal degeneration and good response to oral prednisolone therapy. This case expands the clinical spectrum of CAR.

Indexed as

Cancer associated retinopathyEndometrial carcinomaRetinal degenerationSteroid therapy

Identifiers

PMID33251374
PMCPMC7683230
OpenAlexW3095025179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.