Evidence map›Paper›PMID 33251223›Full record

ArticleFrontiers in cell and developmental biology2020

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation.

Siebe Loontiens, Anne-Catherine Dolens, Steven Strubbe, Inge Van de Walle, Finola E Moore, Lisa Depestel, Suzanne Vanhauwaert, Filip Matthijssens, David M Langenau, Frank Speleman and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  7. Frontiers in oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Siebe LoontiensCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Anne-Catherine DolensDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Steven StrubbeDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Inge Van de WalleDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Finola E MooreMolecular Pathology and Cancer Center, Massachusetts General Hospital, Boston, MA, United States.
Lisa DepestelCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Suzanne VanhauwaertCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Filip MatthijssensCancer Research Institute Ghent (CRIG), Ghent, Belgium.
David M LangenauMolecular Pathology and Cancer Center, Massachusetts General Hospital, Boston, MA, United States.
Frank SpelemanCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Pieter Van VlierbergheCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Kaat DurinckCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Tom TaghonDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Ghent University · BECancer Research Institute Ghent · BEHarvard Stem Cell Institute · USMassachusetts General Hospital · US

Funding

Oncogenic pathways and therapeutic targets in T cell acute lymphoblastic leukemiaR01CA211734 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LANGENAU, DAVID MICHAEL · 2017 to 2021
$1.9M
Translational Immunology Core's FACSAria Cell SorterS10RR023440 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2008 to 2008
$500k
The Role of Phf6 in HematopoiesisF32DK098875 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, FINOLA ELIZABETH · 2013 to 2015
$165k
NCI NIH HHS R01 CA211734NCRR NIH HHS S10 RR023440NIDDK NIH HHS F32 DK098875
6 · The paper itself

Abstract

Transcriptional control of hematopoiesis involves complex regulatory networks and functional perturbations in one of these components often results in malignancies. Loss-of-function mutations in

Indexed as

hematopoiesisNOTCHPHF6T cell developmentzebrafish

Identifiers

PMID33251223
PMCPMC7672048
OpenAlexW3097594063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.