Evidence map›Paper›PMID 33251198›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Regulation of Ptch1 by miR-342-5p and FoxO3 Induced Autophagy Involved in Renal Fibrosis.

Simin Tang, Yi Wang, Guiling Xie, Wenjun Li, Yanna Chen, Jinshu Liang, Pei Liu, Fuhu Song, Jun Zhou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Experimental Study on Danggui Shaoyao San Improving Renal Fibrosis by Promoting Autophagy.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Review
  8. Value of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Simin TangDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Yi WangDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Guiling XieDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Wenjun LiDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Yanna ChenDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Jinshu LiangDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Pei LiuDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Fuhu SongDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Jun ZhouDepartment of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Third Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of renal fibrosis (RF) is not well understood. Here, we performed an integrative database analysis of miRNAs and mRNAs to discover the major regulatory pathway in RF. Putative miRNAs and mRNAs involved in RF in unilateral ureteral obstruction (UUO) model mice were extracted and analyzed using the Gene Expression Omnibus (GEO) database. The bioinformatics analysis suggested that Ptch1 expression is regulated by miR-342-5p and FoxO3. Then real-time PCR, Western blot, Fluorescence

Indexed as

autophagybioinformaticsFOXO3miR-342-5pPtch1renal fibrosis

Identifiers

PMID33251198
PMCPMC7673434
OpenAlexW3095130202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.