Evidence map›Paper›PMID 33251162›Full record

ReviewFrontiers in cellular and infection microbiology2020

Interfering with Autophagy: The Opposing Strategies Deployed by

David R Thomas, Patrice Newton, Nicole Lau, Hayley J Newton

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Quantitative three-dimensional imaging ofInfection and immunity · 2026
    Article
  3. Article
  4. TFEB and MCOLN1 are important forFrontiers in cellular and infection microbiology · 2026
    Article
  5. Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026
    Review
  6. Review
  7. Cryo-EM structure revealed a novel F-actin binding motif in abioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Article
  10. Virulence · 2024
    Article
  11. Article
  12. Autophagy-Related GeneJournal of clinical medicine · 2024
    Article
  13. Breaking the cellular defense: the role of autophagy evasion inFrontiers in cellular and infection microbiology · 2024
    Article
  14. Autophagy: the misty lands ofFrontiers in cellular and infection microbiology · 2024
    Review
  15. Review
  16. Article
  17. Archives of Razi Institute · 2023
    Review
  18. Eat or Be Eaten: Strategies Used byInfection and immunity · 2023
    Review
  19. Article
  20. The intricate dance: host autophagy andFrontiers in microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

David R ThomasDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Patrice NewtonDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Nicole LauDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Hayley J NewtonDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Peter Doherty Institute · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a fundamental and highly conserved eukaryotic process, responsible for maintaining cellular homeostasis and releasing nutrients during times of starvation. An increasingly important function of autophagy is its role in the cell autonomous immune response; a process known as xenophagy. Intracellular pathogens are engulfed by autophagosomes and targeted to lysosomes to eliminate the threat to the host cell. To counteract this, many intracellular bacterial pathogens have developed unique approaches to overcome, evade, or co-opt host autophagy to facilitate a successful infection. The intracellular bacteria

Indexed as

Coxiella burnetiiLegionella pneumophilaLegionnaires' DiseaseAutophagyBacterial ProteinsHost-Pathogen InteractionsHumansVacuolesBacterial ProteinsautophagyCoxiella burnetiieffector proteinLegionella pneumophilatype 4 secretion system (T4SS)

Identifiers

PMID33251162
PMCPMC7676224
OpenAlexW3094750175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.