Evidence map›Paper›PMID 33251120›Full record

ArticleToxicology reports2020

Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy.

Rehab M Abdel-Megeed, Sameh H Abd El-Alim, Azza F Arafa, Azza A Matloub, Abd El Razik H Farrag, Asmaa B Darwish, Abdel-Hamid Z Abdel-Hamid, Mai O Kadry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rehab M Abdel-MegeedTherapeutic Chemistry Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Sameh H Abd El-AlimPharmaceutical Technology Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Azza F ArafaTherapeutic Chemistry Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Azza A MatloubPharmacognosy D Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Abd El Razik H FarragPathology Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Asmaa B DarwishPharmaceutical Technology Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Abdel-Hamid Z Abdel-HamidTherapeutic Chemistry Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
Mai O KadryTherapeutic Chemistry Department, National Research Centre, El-Buhouth St., Cairo, 12622, Egypt.
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomal drug-delivery systems (LDDs) provide a promising opportunity to precisely target organs, improve drug bioavailability and reduce systemic toxicity. On the other hand, PI

Indexed as

AFP, α-fetoproteinAkt, serine/threonine kinaseALP, alkaline phasphataseALT, alanine aminotransferaseAST, aspartate aminotransferaseBad, Bcl-2-associated death promoterCCl4, carbon tetrachlorideC. gilliesii, Caesalpinia gilliesiiDDs, drug-delivery systemsDEN, diethylnitrosamineFOXO1, fork-head box protein O1GM, galactomannanGSH, glutathioneGSK3, glycogen synthase kinaseGST, glutathione S-transferaseHCC, hepatocellular carcinomaHepatocellular carcinomaLDDs, liposomal drug-delivery systemsLiposomal galactomannanLPs, liposomesPI3K/AktPI3K, phosphoinositide 3-kinasePIP2, phosphatidylinositol bisphosphatePIP3, phosphatidylinositol trisphosphatePTENPTEN, phosphatase and tensin homologSTAT 5ASTAT-5A, signal transducer and activator of transcription-5ATEM, transmission electron microscopyVS, vesicle size

Identifiers

PMID33251120
PMCPMC7683274
OpenAlexW3095206917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.