Evidence map›Paper›PMID 33251020›Full record

ArticleJournal of virus eradication2020

HIV-1 resistance patterns to integrase inhibitors in Chilean patients with virological failure on raltegravir-containing regimens.

Pablo Ferrer, Consuelo Rodriguez, Alicia Sciaraffia, Rocío Tordecilla, Veronica Ramos, Magdalena Durán, Carlos Beltrán, Alejandro Afani

Open access · goldAbstract read
In one paragraph

Article in Journal of virus eradication, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pablo FerrerLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Consuelo RodriguezLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Alicia SciaraffiaLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Rocío TordecillaLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Veronica RamosLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Magdalena DuránLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Carlos BeltránGrupo SIDA CHILE, Hospital Ramón Barros Luco y Universidad de Santiago de Chile, Chile.
Alejandro AfaniLaboratorio de Medicina Molecular, Hospital Clínico Universidad de Chile, Santiago, Chile.
Hospital Clínico de la Universidad de Chile · CLUniversidad de Santiago de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this viewpoint we would like to describe our results in terms of resistance pattern in Chilean patients with virological failure (VF) on raltegravir (RAL)-containing-regimens and highlight the need for the concomitant availability of genotypic resistance testing to integrase strand transfer inhibitors (INSTIs) introduction in antiretroviral regimens, particularly in countries in South America. Indeed we found in our study the presence of two or more primary mutations in some of the participants which is associated with cross-resistance to all INSTIs. By using timely genotyping, we could optimally manage these patients, early after detection of VF.

Indexed as

HIVIntegraseIntegrase strand transfer inhibitors (INSTIs)

Identifiers

PMID33251020
PMCPMC7646669
OpenAlexW3037811918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.