Evidence map›Paper›PMID 33250935›Full record

ArticleSport sciences for health2021

Relationship between children physical activity, inflammatory mediators and lymphocyte activation: possible impact of social isolation (COVID-19).

Murilo Merlin, Heloisa Helena de Oliveira, Maria Elizabeth Pereira Passos, Cesar Miguel Momesso, Laiane Cristina Dos Santos de Oliveira, Juliana Exel Santana, Adriana C Levada-Pires, Elaine Hatanaka, Sandro Massao-Hirabara, Renata Guaré and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sport sciences for health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. COVID-19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  3. Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity.International journal of environmental research and public health · 2022
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Murilo MerlinInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.ORCID 0000-0002-6156-4980
Heloisa Helena de OliveiraInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Maria Elizabeth Pereira PassosInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Cesar Miguel MomessoInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Laiane Cristina Dos Santos de OliveiraInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Juliana Exel SantanaDepartment of Biomechanics/Kinesiology and Applied Computer Science, University of Vienna, Vienna, Austria.
Adriana C Levada-PiresInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Elaine HatanakaInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Sandro Massao-HirabaraInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Renata GuaréInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Maria Fernanda Cury-BoaventuraInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Tania C Pithon-CuriInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Renata GorjãoInterdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Rua Galvao Bueno, 868, Liberdade, Sao Paulo, SP 01506-000 Brazil.
Universidade Cruzeiro do Sul · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLifestyle and body composition may be simultaneously responsible for immune response modulation. This study aimed to compare plasmatic adipokines concentration and lymphocyte cytokine production in children with different daily steps (DS) range, as well as to discuss the potential negative impact of the social isolation during COVID-19 pandemic in this context. DS can be a useful and low-cost way of monitoring children's health status. STUDY

designFifty children were classified into clusters based in DS measured by pedometer: Sedentary Group (DS = 9338 ± 902 steps) and Active Group (DS = 13,614 ± 1003 steps). Plasma and lymphocytes were isolated and cultured to evaluate cytokine production.

resultsSedentary group presented lower adiponectin (7573 ± 232 pg/mL), higher leptin (16,250 ± 1825 pg/mL) plasma concentration, and higher lymphocyte production of IL-17, IFN-gamma, TNF-, IL-2 in relation to active group, suggesting predominance of Th1 response. Otherwise, the active group presented higher lymphocyte supernatant concentration of IL-10 and higher regulatory T cell (Treg) percentage.

conclusionThese results indicate that lymphocytes of children performing higher DS have an anti-inflammatory profile, especially of Treg. Besides, the prolonged social isolation in children during the COVID-19 pandemic, limiting physical mobility and exercise, reduces DS and increases adiposity, which could impair the immune system function and raise the susceptibility to inflammatory diseases.

Indexed as

AdipokinesChildhood obesityInflammationMobility reductionPhysical activitySocial isolation

Identifiers

PMID33250935
PMCPMC7681190
OpenAlexW3110309362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.