Evidence map›Paper›PMID 33250929›Full record

ReviewFuture virology2020

Virus spread in the liver: mechanisms, commonalities, and unanswered questions.

Alexi Tallan, Zongdi Feng

Abstract readReview
In one paragraph

Review in Future virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexi TallanCenter for Vaccines & Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Zongdi FengCenter for Vaccines & Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID https://orcid.org/0000-0001-7913-1027

Funding

Mechanism for spread of a quasi-enveloped hepatotropic virusR01AI139511 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FENG, ZONGDI · 2018 to 2022
$2.2M
Immunomodulation by hepatitis E virus free antigenR21AI137912 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI FENG, ZONGDI · 2018 to 2019
$418k
NIAID NIH HHS R01 AI139511NIAID NIH HHS R21 AI137912
6 · The paper itself

Abstract

The liver is home to five known human hepatitis viruses (hepatitis A virus-hepatitis E virus). Despite being phylogenetically unrelated, these viruses replicate and spread in the liver without causing apparent cytopathic effects, and all have evolved strategies to counteract antibody-mediated inhibition of virus spread. In this review, we discuss the current understanding regarding the spread mechanisms for these viruses with an attempt to extract common principles and identify key questions for future studies.

Indexed as

antibody neutralizationcell-to-cell transmissionhepatitis A virushepatitis B virushepatitis C virushepatitis D virushepatitis E virusquasi-envelopmentvirus entryvirus spread

Identifiers

PMID33250929
PMCPMC7675010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.